CAJ | 학술논문

目的：观察多西他赛周疗法联合同步放疗治疗食管癌的临床疗效。方法88例食管癌患者，根据治疗方法的不同分为观察组和对照组，各44例。对照组采用单纯放疗进行治疗；观察组在单纯放疗的基础上采用多西他赛周疗法进行化疗。对比两组患者治疗前后的白细胞介素-6(IL-6)、血清C反应蛋白(CRP)、白细胞介素-8(IL-8)、可溶性MHC-1分子链相关基因A(sMICA)，并比较两组患者治疗后的临床效果。结果治疗后观察组患者的血清CRP、IL-6、IL-8、sMICA水平显著优于对照组，差异具有统计学意义(P<0.05)。观察组患者的治疗效果优于对照组，差异具有统计学意义(P<0.05)。两组患者的不良反应率差异无统计学意义(P>0.05)。患者的不良反应未受到化疗和放疗的影响。结论多西他赛周疗法联合同步放疗治疗食管癌临床效果显著，可以在临床上进一步推广和使用。
목적：관찰다서타새주요법연합동보방료치료식관암적림상료효。방법88례식관암환자，근거치료방법적불동분위관찰조화대조조，각44례。대조조채용단순방료진행치료；관찰조재단순방료적기출상채용다서타새주요법진행화료。대비량조환자치료전후적백세포개소-6(IL-6)、혈청C반응단백(CRP)、백세포개소-8(IL-8)、가용성MHC-1분자련상관기인A(sMICA)，병비교량조환자치료후적림상효과。결과치료후관찰조환자적혈청CRP、IL-6、IL-8、sMICA수평현저우우대조조，차이구유통계학의의(P<0.05)。관찰조환자적치료효과우우대조조，차이구유통계학의의(P<0.05)。량조환자적불량반응솔차이무통계학의의(P>0.05)。환자적불량반응미수도화료화방료적영향。결론다서타새주요법연합동보방료치료식관암림상효과현저，가이재림상상진일보추엄화사용。
Objective To observe clinical effect of docetaxel weekly therapy combined with concurrent radiotherapy in the treatment of esophagus cancer. Methods A total of 88 esophagus cancer patients were divided by different treatment methods into observation group and control group, with 44 cases in each group. The control group received single radiotherapy therapy, and the observation group received additional docetaxel weekly therapy for chemotherapy. Comparisons were made on interleukin-6 (IL-6), serum C-reactive protein (CRP), interleukin-8 (IL-8), soluble MHC-1 chain-related gene A (sMICA) before and after treatment in the two groups, along with their clinical effects. Results After treatment, the observation group had much better levels of serum CRP, IL-6, IL-8, and sMICA than the control group, and their differences had statistical significance (P<0.05). Curative effect was obviously higher in the observation group than in the control group, and the difference had statistical significance (P<0.05). There were no statistically significant difference of adverse reactions rates between the two groups (P>0.05). Adverse reactions in patients were not under the influence by chemotherapy and radiotherapy. Conclusion Docetaxel weekly therapy combined with concurrent radiotherapy provide significant effect in treating esophagus cancer, and this method can be further promoted and applied in clinic.