CAJ | 학술논문

目的：建立SD大鼠胆道梗阻的动物模型，并对该动物模型的肝脏病理变化及肝功能等各项指标进行动态观察。方法将纯系SD大鼠30只，随机分为实验组和对照组，实验组进行胆总管结扎，然后关腹。对照组打开腹部后游离胆总管然后关腹。动态观察胆总管结扎后第1d、3d、7d、14d，21d的肝功能、肝脏组织病理变化。结果梗阻性黄疸大鼠在14d内随着时间延长，血清胆红素逐渐上升，肝内小胆管增生逐步增加，少量纤维结缔组织增生。14d后血清胆红素逐渐下降，增生小胆管减少，亦未见纤维结缔组织增生。结论大鼠梗阻性黄疸在14d内的肝脏病理及肝功能变化与人类相似，但在14d后出现恢复，与人类梗阻性黄疸病变过程不同。
목적：건립SD대서담도경조적동물모형，병대해동물모형적간장병리변화급간공능등각항지표진행동태관찰。방법장순계SD대서30지，수궤분위실험조화대조조，실험조진행담총관결찰，연후관복。대조조타개복부후유리담총관연후관복。동태관찰담총관결찰후제1d、3d、7d、14d，21d적간공능、간장조직병리변화。결과경조성황달대서재14d내수착시간연장，혈청담홍소축점상승，간내소담관증생축보증가，소량섬유결체조직증생。14d후혈청담홍소축점하강，증생소담관감소，역미견섬유결체조직증생。결론대서경조성황달재14d내적간장병리급간공능변화여인류상사，단재14d후출현회복，여인류경조성황달병변과정불동。
Objective To establish the animal models of SD rat biliary obstruction,and pathological changes of liver and liver function indicators on the animal model of dynamic observation. Methods The pure line of 35 SD rats,were randomly divided into experimental group and control group,the experimental group underwent common bile duct ligation,then close the abdominal. The control group after open abdomen from the common bile duct and abdominal closure. Dynamic observation of bile duct ligation af-ter first days,3 days,7 days,14 days,21 days of liver function,pathological changes of hepatic tissues. Results In rats with ob-structive jaundice in 14 days with the prolongation of time,serum bilirubin increased gradually,the small intrahepatic bile duct proliferation increased gradually,with little fibrous connective tissue hyperplasia. After 14 days of serum bilirubin decreased grad-ually,small bile duct hyperplasia reduce,also has not seen the hyperplasia of fibrous connective tissue. Conclusion Jaundice Rat Liver and liver function obstruction in 14 days changes similar to humans,but in 14 days after the surgery the rats appeared re-covery,unlike human obstructive jaundice disease process.