临床合理用药杂志
臨床閤理用藥雜誌
림상합리용약잡지
CHINESE JOURNAL OF CLINICAL RATIONAL DRUG USE
2015年
24期
30-31
,共2页
哮喘%儿童%孟鲁司特钠%布地奈德%治疗结果
哮喘%兒童%孟魯司特鈉%佈地奈德%治療結果
효천%인동%맹로사특납%포지내덕%치료결과
Asthma%Child%Montelukast%Budesonide%Treatment outcome
目的：探讨孟鲁司特钠联合布地奈德雾化吸入治疗小儿咳嗽变异性哮喘（ CAV）的临床疗效。方法选取2013年1月—2014年1月双流县第一人民医院收治的 CAV 患儿76例，随机分为治疗组（39例）与对照组（37例）。对照组患儿予以布地奈德雾化吸入治疗，治疗组患儿在对照组基础上加用孟鲁司特钠治疗。观察两组患儿咳嗽症状缓解时间、症状消失时间、临床疗效、不良反应发生情况及复发情况（复发率、复发时间）。结果治疗组患儿咳嗽症状缓解时间、症状消失时间短于对照组，差异有统计学意义（ P ﹤0.05）；治疗组患儿总有效率高于对照组，差异有统计学意义（P ﹤0.05）；两组患儿不良反应发生率比较，差异无统计学意义（P ﹥0.05）；两组患儿复发率比较，差异无统计学意义（P ﹥0.05）；治疗组患儿复发时间长于对照组，差异有统计学意义（P ﹤0.05）。结论孟鲁司特钠联合布地奈德雾化吸入治疗小儿 CAV 的临床疗效显著，可有效改善患儿临床症状，延长复发时间。
目的：探討孟魯司特鈉聯閤佈地奈德霧化吸入治療小兒咳嗽變異性哮喘（ CAV）的臨床療效。方法選取2013年1月—2014年1月雙流縣第一人民醫院收治的 CAV 患兒76例，隨機分為治療組（39例）與對照組（37例）。對照組患兒予以佈地奈德霧化吸入治療，治療組患兒在對照組基礎上加用孟魯司特鈉治療。觀察兩組患兒咳嗽癥狀緩解時間、癥狀消失時間、臨床療效、不良反應髮生情況及複髮情況（複髮率、複髮時間）。結果治療組患兒咳嗽癥狀緩解時間、癥狀消失時間短于對照組，差異有統計學意義（ P ﹤0.05）；治療組患兒總有效率高于對照組，差異有統計學意義（P ﹤0.05）；兩組患兒不良反應髮生率比較，差異無統計學意義（P ﹥0.05）；兩組患兒複髮率比較，差異無統計學意義（P ﹥0.05）；治療組患兒複髮時間長于對照組，差異有統計學意義（P ﹤0.05）。結論孟魯司特鈉聯閤佈地奈德霧化吸入治療小兒 CAV 的臨床療效顯著，可有效改善患兒臨床癥狀，延長複髮時間。
목적：탐토맹로사특납연합포지내덕무화흡입치료소인해수변이성효천（ CAV）적림상료효。방법선취2013년1월—2014년1월쌍류현제일인민의원수치적 CAV 환인76례，수궤분위치료조（39례）여대조조（37례）。대조조환인여이포지내덕무화흡입치료，치료조환인재대조조기출상가용맹로사특납치료。관찰량조환인해수증상완해시간、증상소실시간、림상료효、불량반응발생정황급복발정황（복발솔、복발시간）。결과치료조환인해수증상완해시간、증상소실시간단우대조조，차이유통계학의의（ P ﹤0.05）；치료조환인총유효솔고우대조조，차이유통계학의의（P ﹤0.05）；량조환인불량반응발생솔비교，차이무통계학의의（P ﹥0.05）；량조환인복발솔비교，차이무통계학의의（P ﹥0.05）；치료조환인복발시간장우대조조，차이유통계학의의（P ﹤0.05）。결론맹로사특납연합포지내덕무화흡입치료소인 CAV 적림상료효현저，가유효개선환인림상증상，연장복발시간。
Objective To explore the effect of montelukast combined with budesonide aerosol inhalation treatment of children with cough variant asthma(CAV). Methods A total of 76 children with CAV were selected in the First People's Hospital of Shuangliu County from January 2013 to January 2014 ,they were randomly divided into treatment group(39 cases) and control group(37 cases). Control group were given budesonide aerosol inhalation treatment,treatment group were given montelukast treatment on the basis of control group. Cough symptoms remission time,symptom disappearance time,clinical effect,incidence of adverse reactions and recurrence were observed(recurrence rate,recurrence time)between the two groups were compared. Results Cough symptoms remission time and symptom disappearance time of treatment group were shorter than that of control group(P ﹤ 0. 05);the total effective rate of treatment group was higher than that of control group(P ﹤ 0. 05);incidence of adverse reactions showed no significant differences between the two groups(P ﹥ 0. 05);recurrence rate showed no significant differences between the two groups(P ﹥ 0. 05);recurrence time of treatment group was longer than that of control group(P ﹤ 0. 05). Conclusion Montelukast combined with budesonide aerosol inhalation have notable curative effect in the treatment of children with CAV,can improve clinical symptoms and prolong the time to relapse.
