CAJ | 학술논문

目的：探讨右美托咪定减轻全麻苏醒期拔管反应的临床效果。方法气管内插管全麻术后入麻醉恢复室（PACU）的病人200例随机分为2组，右美托咪定组（A组）和对照组（B组），各100例。A组入PACU时即给予右美托咪定0.5μg/kg，10min 泵注完毕；B组给予同等剂量的生理盐水。记录入PACU时基础值(T0)、拔管时(T1)、拔管后5min (T2)、拔管后30min(T3)不同时间点患者的血压、心率、脉氧饱和度，记录苏醒时间、拔管时间。结果 A组 T1、T2时间点血压和心率与B组相比降低(P<0.05)，A组苏醒时间、拔管时间与B组相比无统计学差异(P<0.05)。结论右美托咪定可以减轻全麻苏醒期拔管反应。
목적：탐토우미탁미정감경전마소성기발관반응적림상효과。방법기관내삽관전마술후입마취회복실（PACU）적병인200례수궤분위2조，우미탁미정조（A조）화대조조（B조），각100례。A조입PACU시즉급여우미탁미정0.5μg/kg，10min 빙주완필；B조급여동등제량적생리염수。기록입PACU시기출치(T0)、발관시(T1)、발관후5min (T2)、발관후30min(T3)불동시간점환자적혈압、심솔、맥양포화도，기록소성시간、발관시간。결과 A조 T1、T2시간점혈압화심솔여B조상비강저(P<0.05)，A조소성시간、발관시간여B조상비무통계학차이(P<0.05)。결론우미탁미정가이감경전마소성기발관반응。
Objective To observe the clinic effects of dexmedetomidine on patients after general anesthesia during endotra-cheal extubation. Methods 200 patients with endotracheal intubation in post-anesthesia-care-unit(PACU) were randomly divided into two groups. At the time to PACU,dexmedetomidine at a dose of 0.5μg/kg in Group A (Ddexmedetomidine Group,n=100) and saline in Group B (control Group n=100) were administrated intravenously in 10mins. BP,HR,SpO2 were recorded at different time:time to PACU(T0),time to extubation(T1),5mins after extubation(T2),30mins after extubation(T3). The time of palinesthesia and extubation were recorded too. Results The BP and HR of Group A were lower than Group B at time T1、T2 (P<0.05). There was no difference on the time of palinesthesia and extubation between two groups (P>0.05). Conclusion Dexmedetomidine used in PACU could depress extubation reaction.