浙江化工
浙江化工
절강화공
ZHEJIANG CHEMICAL INDUSTRY
2015年
8期
26-29
,共4页
程益民%鲍家馨%谢建武
程益民%鮑傢馨%謝建武
정익민%포가형%사건무
二氢呋喃衍生物%溴代试剂%-溴代丙二酸二乙酯%环化反应
二氫呋喃衍生物%溴代試劑%-溴代丙二痠二乙酯%環化反應
이경부남연생물%추대시제%-추대병이산이을지%배화반응
dihydrofurans%bromination reagent%diethylα-bromomalonate%cyclization reaction
在温和的条件下，以-溴代丙二酸二乙酯、三乙胺为溴代试剂和碱为原料，高效合成了螺二氢呋喃衍生物，并获得了较好的收率(68%~91%)。该类化合通过核磁共振及单晶衍射（X-Ray）确定了结构，并对反应机理进行了推测。
在溫和的條件下，以-溴代丙二痠二乙酯、三乙胺為溴代試劑和堿為原料，高效閤成瞭螺二氫呋喃衍生物，併穫得瞭較好的收率(68%~91%)。該類化閤通過覈磁共振及單晶衍射（X-Ray）確定瞭結構，併對反應機理進行瞭推測。
재온화적조건하，이-추대병이산이을지、삼을알위추대시제화감위원료，고효합성료라이경부남연생물，병획득료교호적수솔(68%~91%)。해류화합통과핵자공진급단정연사（X-Ray）학정료결구，병대반응궤리진행료추측。
An efficient method for the synthesis of spiro dihydrofuran derivatives was demonstrated, based on a novel bromination reagent (diethyl-bromomalonate) and base under mild conditions. The products were obtained in excellent yield (68%~91%). The structure of spiro dihydrofuran derivatives was established by NMR and X-ray. A possible mechanism of this unusual reaction process was proposed.
