CAJ | 학술논문

综述了合成具有生物活性的二氢异喹啉和四氢异喹啉类化合物的最常用方法-Bischler-Napieralski 反应。该方法底物简单易得，反应性好，可应用于工业化生产。介绍了应用于Bischler-Napieralski 反应的不同氯代试剂，以及研究者们对Bischler-Napieralski 反应应用范围的拓展，即将其应用于合成具有生物活性的五元和七元杂环化合物。
종술료합성구유생물활성적이경이규람화사경이규람류화합물적최상용방법-Bischler-Napieralski 반응。해방법저물간단역득，반응성호，가응용우공업화생산。개소료응용우Bischler-Napieralski 반응적불동록대시제，이급연구자문대Bischler-Napieralski 반응응용범위적탁전，즉장기응용우합성구유생물활성적오원화칠원잡배화합물。
We review the progress on the most commonly used procedure for synthesizing biologically active dihydroisoquinolines and tetrahydroisoquinolines- Bischler-Napieralski reaction. The reaction was usually applied to the industrial production because the substrates with good reactivity are simple and can be obtained easily. We introduce the different chlorinating reagents that can be applied to the Bischler-Napieralski reaction, and summarize researchers’ efforts on expanding the new application for synthesis of five-membered and seven-membered ring heterocyclic compounds with biological activities.