CAJ | 학술논문

目的：探讨白蛋白联合呋塞米治疗大面积脑梗死的疗效及安全性。方法100例诊断为大面积脑梗死的患者作为本次研究对象，按随机号码表法分为研究组和对照组，各50例。研究组接受白蛋白联合呋塞米脱水，对照组接受甘露醇脱水。对比两组治疗前、后神经功能缺损评分及血液流变学；使用利尿剂期间不良反应发生情况。结果研究组和对照组治疗前神经功能缺损评分及血浆粘度、红细胞比容差异无统计学意义(P>0.05)；治疗后神经功能缺损评分及血浆粘度、红细胞比容差异有统计学意义(P<0.05)。研究组和对照组不良反应发生率分别为4%、16%，差异有统计学意义(P<0.05)。结论白蛋白联合呋塞米治疗大面积脑梗死疗效可靠，安全性高，值得临床推广应用。
목적：탐토백단백연합부새미치료대면적뇌경사적료효급안전성。방법100례진단위대면적뇌경사적환자작위본차연구대상，안수궤호마표법분위연구조화대조조，각50례。연구조접수백단백연합부새미탈수，대조조접수감로순탈수。대비량조치료전、후신경공능결손평분급혈액류변학；사용이뇨제기간불량반응발생정황。결과연구조화대조조치료전신경공능결손평분급혈장점도、홍세포비용차이무통계학의의(P>0.05)；치료후신경공능결손평분급혈장점도、홍세포비용차이유통계학의의(P<0.05)。연구조화대조조불량반응발생솔분별위4%、16%，차이유통계학의의(P<0.05)。결론백단백연합부새미치료대면적뇌경사료효가고，안전성고，치득림상추엄응용。
Objective To investigate curative effect and safety of albumin combined with furosemide in the treatment of massive cerebral infarction. Methods A total of 100 diagnosed massive cerebral infarction patients as study subjects were randomly divided into research group and control group, with 50 cases in each group. The research group received albumin combined with furosemide dehydration, and the control group received mannitol dehydration. Comparisons were made on national institutes of health stroke scale, hemorheology, and adverse reactions during diuretic application between the two groups before and after treatment. Results There were no statistically significant differences of national institutes of health stroke scale, plasma viscosity, and hematocrit value between the two groups before treatment (P>0.05). The differences of national institutes of health stroke scale plasma viscosity, and hematocrit value had statistical significance between the research group and the control group after treatment (P<0.05). Incidence of adverse reactions was 4%in the research group, and was 16%in the control group. Their difference had statistical significance (P<0.05). Conclusion Combination of albumin and furosemide provides reliable effect and high safety in the treatment of massive cerebral infarction, and this method is worthy of clinical promotion and application.