包头医学院学报
包頭醫學院學報
포두의학원학보
JOURNAL OF BAOTOU MEDICAL COLLEGE
2015年
8期
3-3,8
,共2页
脑胶质瘤%ADAM17%EGFR
腦膠質瘤%ADAM17%EGFR
뇌효질류%ADAM17%EGFR
Glioma%ADAM17%EGFR
目的：：探讨解聚素-金属蛋白酶(ADAM17)和表皮生长因子受体(EGFR)在脑胶质瘤的表达及意义。方法：实验分为对照组(脑外伤手术减压的脑组织， n =5)、低度恶性胶质瘤组(Ⅰ~Ⅱ级， n =5)和高度恶性胶质瘤组(Ⅲ~Ⅳ级， n =5)，采用免疫印迹法检测各组ADAM17和EGFR水平。结果：ADAM17和EGFR在对照组微弱表达或不表达，在低度恶性胶质瘤组中表达增高，两组间比较差异有统计学意义( P <0.01)；在高度恶性胶质瘤组中表达进一步增多，与低度恶性胶质瘤组比较差异有统计学意义( P <0.01)。结论：ADAM17和EGFR在人脑胶质瘤中表达增高，且与胶质瘤的恶性程度相关。
目的：：探討解聚素-金屬蛋白酶(ADAM17)和錶皮生長因子受體(EGFR)在腦膠質瘤的錶達及意義。方法：實驗分為對照組(腦外傷手術減壓的腦組織， n =5)、低度噁性膠質瘤組(Ⅰ~Ⅱ級， n =5)和高度噁性膠質瘤組(Ⅲ~Ⅳ級， n =5)，採用免疫印跡法檢測各組ADAM17和EGFR水平。結果：ADAM17和EGFR在對照組微弱錶達或不錶達，在低度噁性膠質瘤組中錶達增高，兩組間比較差異有統計學意義( P <0.01)；在高度噁性膠質瘤組中錶達進一步增多，與低度噁性膠質瘤組比較差異有統計學意義( P <0.01)。結論：ADAM17和EGFR在人腦膠質瘤中錶達增高，且與膠質瘤的噁性程度相關。
목적：：탐토해취소-금속단백매(ADAM17)화표피생장인자수체(EGFR)재뇌효질류적표체급의의。방법：실험분위대조조(뇌외상수술감압적뇌조직， n =5)、저도악성효질류조(Ⅰ~Ⅱ급， n =5)화고도악성효질류조(Ⅲ~Ⅳ급， n =5)，채용면역인적법검측각조ADAM17화EGFR수평。결과：ADAM17화EGFR재대조조미약표체혹불표체，재저도악성효질류조중표체증고，량조간비교차이유통계학의의( P <0.01)；재고도악성효질류조중표체진일보증다，여저도악성효질류조비교차이유통계학의의( P <0.01)。결론：ADAM17화EGFR재인뇌효질류중표체증고，차여효질류적악성정도상관。
Objective:To investigate the expression and significance of ADAM17 and EGFR in human glioma. Methods:There were three groups in the experiments, the control group (surgical decompress brain tissue of brain injury, n =5), the low-grade malignant glioma group (Ⅰ~Ⅱgrade, n =5) and the high-grade malignant glioma group (Ⅲ~Ⅳgrade, n =5). The level of expression of DAM17 and EGFR was detected by western blotting. Results:There was weak expression of ADAM17 and no expression of EGFR in the control group. Compared with the control group, the ex-pressions of ADAM17 and EGFR in the low-grade group increased, and there was a significant difference between the two groups. Compared with the low-grade group, the expressions in the high-grade group further increased, with significant difference in the two groups. Conclusion:The expres-sions of ADAM17 and EGFR increase in human brain glioma, which has the close correlation to the degree of malignance in glioma.
