CAJ | 학술논문

目的：了解肝硬化伴全身炎性反应综合征(SIRS)患者C反应蛋白(CRP)、降钙素原(PCT)、白细胞介素6(IL-6)水平,探讨各指标预测预后的能力。方法收集肝硬化伴 SIRS 患者56例,依预后分为好转组39例,死亡组17例,出现 SIRS 后第1、3、7天检测 CRP、PCT、IL-6水平,观察 CRP、PCT、IL-6与预后的关系。结果第1天两组比较 CRP、PCT、IL-6差异均无统计学意义(P >0.05)；第3天两组相比较 PCT、IL-6差异无统计学意义(P >0.05),好转组 CRP 明显下降(P <0.05)；第7天两组CRP、PCT、IL-6比较,好转组均明显低于死亡组(P <0.05)。同组相比,死亡组 CRP、PCT、IL-6第1天、第3天、第7天检测值差异无统计学意义(P >0.05)；好转组 PCT、IL-6第3天与第1天相比差异无统计学意义(P >0.05),CRP 第3天、第7天明显下降(P <0.05),好转组 PCT、IL-6第7天与第1天相比显著下降(P <0.05)。结论CRP、PCT、IL-6的持续高水平提示预后不良；与PCT、IL-6相比,CRP 更能迅速反应病情改善。
목적：료해간경화반전신염성반응종합정(SIRS)환자C반응단백(CRP)、강개소원(PCT)、백세포개소6(IL-6)수평,탐토각지표예측예후적능력。방법수집간경화반 SIRS 환자56례,의예후분위호전조39례,사망조17례,출현 SIRS 후제1、3、7천검측 CRP、PCT、IL-6수평,관찰 CRP、PCT、IL-6여예후적관계。결과제1천량조비교 CRP、PCT、IL-6차이균무통계학의의(P >0.05)；제3천량조상비교 PCT、IL-6차이무통계학의의(P >0.05),호전조 CRP 명현하강(P <0.05)；제7천량조CRP、PCT、IL-6비교,호전조균명현저우사망조(P <0.05)。동조상비,사망조 CRP、PCT、IL-6제1천、제3천、제7천검측치차이무통계학의의(P >0.05)；호전조 PCT、IL-6제3천여제1천상비차이무통계학의의(P >0.05),CRP 제3천、제7천명현하강(P <0.05),호전조 PCT、IL-6제7천여제1천상비현저하강(P <0.05)。결론CRP、PCT、IL-6적지속고수평제시예후불량；여PCT、IL-6상비,CRP 경능신속반응병정개선。
Objective To detect the serum levels of C-reactive protein (CRP),procalcitonin (PCT),and interleukin-6(IL-6) and evaluate their prognostic values in liver cirrhosis with systemic inflammatory response syndrome(SIRS).Methods A total of 56 patients with liver cirrhosis and systemic inflammatory response syndrome were divided into two groups,improved group(n =39)and death group(n=1 7).Serum CRP、PCT、IL-6 levels were measured at the first day,third day and seventh day after SIRS. Results CRP,PCT and IL-6 levels of two groups were no statistically significant difference in the first day (P >0.05).PCT and IL-6 levels of two groups were no statistically significant difference in the third day (P >0.05).CRP levels in improved group were lower than those in death group in the third day (P <0.05).CRP,PCT and IL-6 levels in improved group were lower than those in death group in the seventh day (P <0.05).There was no statistically significant difference of CRP,PCT and IL-6 at the first day, third day and seventh day in death group (P >0.05).CRP levels at the third day and seventh day were lower than those at the first day in improved group (P <0.05).PCT and IL-6 levels at the seventh day were lower than those at the first day in improved group (P <0.05).Conclusion Poor prognosis was showed at sustained high levels of CRP,PCT and IL-6.Compared with PCT and IL-6, CRP might be more rapid in showing condition improved.