CAJ | 학술논문

目的：探讨经自制带侧孔的快速交换球囊导管靶向注射替罗非班联合硝普钠对择期冠状动脉介入治疗(PCI)术中无复流(NR)的即刻疗效。方法选择2013年1月至2014年8月在该中心行择期 PCI 治疗中发生无复流的患者49例,随机分为经球囊导管给药组25例,经指引导管给药组24例。两组患者均给予替罗非班及硝普钠。评价给药前后冠状动脉血流心肌梗死溶栓试验(TIMI)分级及校正 TIMI 帧数(CTFC)。结果给药10 min 后,经球囊导管给药组有21例(84.0%)达到 TIMI 3级血流,校正 CTFC 为(33.5±12.5)帧,而经指引导管给药组有13例(54.2%)达到 TIMI 3级血流,CTFC 为(41.9±15.3)帧,两组比较差异有统计学意义(P <0.05)。结论经自制带侧孔球囊导管靶向注射替罗非班联合硝普钠较经指引导管给药更能有效地改善择期 PCI 术中无复流患者冠状动脉的即刻血流。
목적：탐토경자제대측공적쾌속교환구낭도관파향주사체라비반연합초보납대택기관상동맥개입치료(PCI)술중무복류(NR)적즉각료효。방법선택2013년1월지2014년8월재해중심행택기 PCI 치료중발생무복류적환자49례,수궤분위경구낭도관급약조25례,경지인도관급약조24례。량조환자균급여체라비반급초보납。평개급약전후관상동맥혈류심기경사용전시험(TIMI)분급급교정 TIMI 정수(CTFC)。결과급약10 min 후,경구낭도관급약조유21례(84.0%)체도 TIMI 3급혈류,교정 CTFC 위(33.5±12.5)정,이경지인도관급약조유13례(54.2%)체도 TIMI 3급혈류,CTFC 위(41.9±15.3)정,량조비교차이유통계학의의(P <0.05)。결론경자제대측공구낭도관파향주사체라비반연합초보납교경지인도관급약경능유효지개선택기 PCI 술중무복류환자관상동맥적즉각혈류。
Objective To investigate the effects of tirofiban combined with nitroprusside injection through the rapid exchange balloon catheter with self-made side holes on no-reflow (NR)phenomenon during elective percutaneous coronary intervention (PCI).Methods A total of 49 patients with NR phenomenon were randomly divided into the balloon catheter group (n=25)and the guiding catheter group (n=24).Tirofiban combined with nitroprusside were used in both groups.Thrombolysis in myocardial infarction (TIMI)grade and corrected TIMI frame count (CTFC)of target coronary artery at 10 minutes after administration were assessed.Results At 10 minutes after drugs injection,there were 21 (84.0%)patients with target of coronary TIMI 3 grade in the balloon catheter group,and 13 (54.2%)patients in the guiding catheter group.The CTFC was (33.5±12.5)frame in the balloon catheter group,and (41.9±1 5.3)frame in the guiding catheter group.The difference in TIMI and CTFC between the two groups was significantly (P <0.05).Conclusion Injection tirofiban combined with nitroprusside through the rapid exchange balloon cathe-ter with self-made side holes in NR patients during elective PCI might be feasible and effective.