白血病·淋巴瘤
白血病·淋巴瘤
백혈병·림파류
JOURNAL OF LEUKEMIA & LYMPHOMA
2015年
7期
424-427
,共4页
周莉莉%傅建非%吴昊%李冰%梁爱斌
週莉莉%傅建非%吳昊%李冰%樑愛斌
주리리%부건비%오호%리빙%량애빈
骨髓增殖性肿瘤%蛋白酪氨酸磷酸酶1B%DNA测序
骨髓增殖性腫瘤%蛋白酪氨痠燐痠酶1B%DNA測序
골수증식성종류%단백락안산린산매1B%DNA측서
Myeloproliferative neoplasms%Protein tyrosine phosphatase 1B%DNA sequencing
目的 分析骨髓增殖性肿瘤(MPN)患者中蛋白酪氨酸磷酸酶1B(PTP1B)基因突变情况.方法 采用DNA测序技术检测84例MPN患者及37例健康对照者PTP1B的DNA序列.结果 MPN患者及健康对照者均未检测到Exon1 ~6、Exon9和Exon10突变.MPN患者中有18例检测到Exon8 C/T杂合性突变,健康对照者中有10例检测到C/T杂合性突变,两组之间差异无统计学意义(x 2=0.453,P=0.501).38例患者进行了Exon7基因测序,2例有C/T杂合性突变,健康对照者中有1例G/C杂合性突变.所有受试者均未检测到纯合性突变.结论 MPN患者PTP1B基因突变与健康对照者相比没有明显差异.
目的 分析骨髓增殖性腫瘤(MPN)患者中蛋白酪氨痠燐痠酶1B(PTP1B)基因突變情況.方法 採用DNA測序技術檢測84例MPN患者及37例健康對照者PTP1B的DNA序列.結果 MPN患者及健康對照者均未檢測到Exon1 ~6、Exon9和Exon10突變.MPN患者中有18例檢測到Exon8 C/T雜閤性突變,健康對照者中有10例檢測到C/T雜閤性突變,兩組之間差異無統計學意義(x 2=0.453,P=0.501).38例患者進行瞭Exon7基因測序,2例有C/T雜閤性突變,健康對照者中有1例G/C雜閤性突變.所有受試者均未檢測到純閤性突變.結論 MPN患者PTP1B基因突變與健康對照者相比沒有明顯差異.
목적 분석골수증식성종류(MPN)환자중단백락안산린산매1B(PTP1B)기인돌변정황.방법 채용DNA측서기술검측84례MPN환자급37례건강대조자PTP1B적DNA서렬.결과 MPN환자급건강대조자균미검측도Exon1 ~6、Exon9화Exon10돌변.MPN환자중유18례검측도Exon8 C/T잡합성돌변,건강대조자중유10례검측도C/T잡합성돌변,량조지간차이무통계학의의(x 2=0.453,P=0.501).38례환자진행료Exon7기인측서,2례유C/T잡합성돌변,건강대조자중유1례G/C잡합성돌변.소유수시자균미검측도순합성돌변.결론 MPN환자PTP1B기인돌변여건강대조자상비몰유명현차이.
Objective To analyse protein tyrosine phosphatase 1B (PTP1B) gene mutation in myeloproliferative neoplasms (MPN).Methods DNA sequencing technology was used to detect DNA sequences of PTP1B in MPN patients (n =84) and normal controls (n =37).Results For Exon1-6,Exon9 and Exon10,84 cases of MPN patients and 37 cases of control group were not detected mutation.For EXON 8,18 of 84 MPN patients had Exon8 C/T heterozygous mutation and 10 of 37 normal controls were detected C/T heterozygous mutation.There was no significant difference between MPN patients and normal controls (x2 =0.453,P =0.501).Exon7 was detected in 38 MPN patients and 2 cases of patients were found C/T heterozygous mutation,while in the control group,1 case with G/C heterozygous mutation.All of the cases were not detected homozygous mutation.Conclusion Using DNA sequencing technology to detect gene mutations of PTP1B,there is no significant difference between MPN patients and normal controls.