CAJ | 학술논문

目的：总结分析2例原发性血小板增多症患者妊娠期及围产期的治疗过程，并进行相关文献复习。方法评估2例妊娠原发性血小板增多症患者，根据患者危险度分层，在妊娠期及围产期分别给予个体化治疗。结果1例高危患者妊娠期全程给予低分子肝素及干扰素α-2 b 治疗，另1例低危患者妊娠期全程给予阿司匹林及干扰素α-2 b 治疗；2例患者均安全娩出胎儿，产后12小时应用低分子肝素至围产期结束。结论原发性血小板增多患者妊娠期及围产期极易出现各种并发症，需在血液科和产科医生的合作下，根据患者危险度分层给予全程个体化治疗、合理用药。
목적：총결분석2례원발성혈소판증다증환자임신기급위산기적치료과정，병진행상관문헌복습。방법평고2례임신원발성혈소판증다증환자，근거환자위험도분층，재임신기급위산기분별급여개체화치료。결과1례고위환자임신기전정급여저분자간소급간우소α-2 b 치료，령1례저위환자임신기전정급여아사필림급간우소α-2 b 치료；2례환자균안전면출태인，산후12소시응용저분자간소지위산기결속。결론원발성혈소판증다환자임신기급위산기겁역출현각충병발증，수재혈액과화산과의생적합작하，근거환자위험도분층급여전정개체화치료、합리용약。
Objective To present the treatment of two essential thrombocythemia (ET) patients during gestation period and perinatal period, and analyze the rational medication. Methods Evaluated two ET patients, and individualized ther-apies were given during the gestation period and perinatal period according to the risk stratification. Results To the high risk patient, low molecular weight heparin (LMWH) and interferon α-2 b were applied during the whole ges-tation period; to the low risk patient, aspirin and interferon α-2 b were applied during the whole gestation period. Both patients delivered the fetus successfully, and LMWH was used from 12 hours to 6 weeks after delivery. Conclu-sion ET patients during gestation period and perinatal period are at high risk of complications. Evaluation of the prog-nosis, individualized treatment and rational drug use is required, by the cooperation of hematologists and obstetrists.