中国药物警戒
中國藥物警戒
중국약물경계
CHINESE JOURNAL OF PHARMACOVIGILANCE
2015年
8期
497-499
,共3页
前列地尔%药品不良反应%合理给药
前列地爾%藥品不良反應%閤理給藥
전렬지이%약품불량반응%합리급약
alprostadil%adverse drug reaction(ADR)%rational administration
目的：分析前列地尔不良反应的临床特点和相关因素，为临床预防及治疗提供参考。方法检索我院2010至2014年收到的前列地尔不良反应报告（ADR），分析患者的性别、年龄、原患疾病、前列地尔规格及用药剂量、给药方式、临床表现、关联性评价、处置方法和预后。结果共收集到前列地尔不良反应100例。100例患者中男性56例，平均年龄（53.8±16.5）岁，女性44例，平均年龄（56.9±14.5）岁。原患疾病主要为骨折20例、肾病19例、静脉曲张13例。前列地尔用药剂量10μg·d-1（2例）和20μg·d-1（27例）。96例患者采用静脉滴注，4例采用静脉注射。用药时间中位数为2 d（2.9±2.8）d。不良反应临床表现主要为心外血管系统损害，占62.4%。100例 ADR，“肯定”2例；“很可能”47例；“可能”51例。不良反应治疗方法包括停药、外敷、吸氧、静注糖皮质激素等。100份报告预后结果，其中17例治愈，83例好转。结论前列地尔不良反应时有发生，临床应该注意前列地尔的正确保存和使用，并应加强前列地尔不良反应的监测。
目的：分析前列地爾不良反應的臨床特點和相關因素，為臨床預防及治療提供參攷。方法檢索我院2010至2014年收到的前列地爾不良反應報告（ADR），分析患者的性彆、年齡、原患疾病、前列地爾規格及用藥劑量、給藥方式、臨床錶現、關聯性評價、處置方法和預後。結果共收集到前列地爾不良反應100例。100例患者中男性56例，平均年齡（53.8±16.5）歲，女性44例，平均年齡（56.9±14.5）歲。原患疾病主要為骨摺20例、腎病19例、靜脈麯張13例。前列地爾用藥劑量10μg·d-1（2例）和20μg·d-1（27例）。96例患者採用靜脈滴註，4例採用靜脈註射。用藥時間中位數為2 d（2.9±2.8）d。不良反應臨床錶現主要為心外血管繫統損害，佔62.4%。100例 ADR，“肯定”2例；“很可能”47例；“可能”51例。不良反應治療方法包括停藥、外敷、吸氧、靜註糖皮質激素等。100份報告預後結果，其中17例治愈，83例好轉。結論前列地爾不良反應時有髮生，臨床應該註意前列地爾的正確保存和使用，併應加彊前列地爾不良反應的鑑測。
목적：분석전렬지이불량반응적림상특점화상관인소，위림상예방급치료제공삼고。방법검색아원2010지2014년수도적전렬지이불량반응보고（ADR），분석환자적성별、년령、원환질병、전렬지이규격급용약제량、급약방식、림상표현、관련성평개、처치방법화예후。결과공수집도전렬지이불량반응100례。100례환자중남성56례，평균년령（53.8±16.5）세，녀성44례，평균년령（56.9±14.5）세。원환질병주요위골절20례、신병19례、정맥곡장13례。전렬지이용약제량10μg·d-1（2례）화20μg·d-1（27례）。96례환자채용정맥적주，4례채용정맥주사。용약시간중위수위2 d（2.9±2.8）d。불량반응림상표현주요위심외혈관계통손해，점62.4%。100례 ADR，“긍정”2례；“흔가능”47례；“가능”51례。불량반응치료방법포괄정약、외부、흡양、정주당피질격소등。100빈보고예후결과，기중17례치유，83례호전。결론전렬지이불량반응시유발생，림상응해주의전렬지이적정학보존화사용，병응가강전렬지이불량반응적감측。
Objective To provide references for clinical prevention and treatment by analyzing the clinical features and related factors of adverse drug reactions due to alprostadil. Methods The incidences of ADRs caused by alprostadil reported in the hospital from 2010 to 2014 were analyzed in terms of gender, age, primary disease, specification and dosage, the method of administration, clinical manifestation, relevance evaluation, treatment and prognosis. Results Totally, 100 cases of ADR caused by alprostadil were reported. In 100 patients, 56 cases were male, average age was (65.5+1.7) years old, while 44 cases was female, average age was (52.5 + 26.5) years old. Mainly primary disease were fracture (20 cases), nephropathy (19 cases), varicose vein (13 cases). Alprostadil doses were 10 μg·d-1 (2 cases) and 20 μg·d-1 (27 cases). 96 patients were treated with intravenous infusion, 4 cases with intravenous injection. Medication time was 2 d (2.9 + 2.8) d. Clinical manifestations of adverse reactions were mainly cardiac vascular system damage, accounting for 62.4%. In all 100 cases of ADR, 2 cases were "must", 47 cases "very likely", 51 cases "possible". Treatment methods of adverse reaction were withdrawal, external application, oxygen inhalation, intravenous injection of glucocorticoid. Among the outcomes, 17 cases were cured, 83 cases improved. Conclusion Adverse reactions of alprostadil have occurred from time to time, clinical attention should be paid to the proper preservation and use of alprostadil and alprostadil adverse reactions monitoring.
