中国医学创新
中國醫學創新
중국의학창신
MEDICAL INNOVATION OF CHINA
2015年
24期
93-94
,共2页
皮回春%吴曼祯%高玉山%林伟敏
皮迴春%吳曼禎%高玉山%林偉敏
피회춘%오만정%고옥산%림위민
免费产前筛查%产前诊断%无创基因检测%唐氏筛查
免費產前篩查%產前診斷%無創基因檢測%唐氏篩查
면비산전사사%산전진단%무창기인검측%당씨사사
Prenatal screening for free%Prenatal diagnosis%Noninvasive genetic testing%Down’s syndrome screening
目的：分析近2年深圳市龙岗区免费产前筛查与产前诊断的情况，优化筛查方案和流程。方法：对深圳市龙岗区2012年11月-2013年7月3431例进行免费无创基因检测孕妇和2014年3月-2015年2月23746例免费产前血清学筛查孕妇的资料进行分析，分别统计各自筛查出的13三体、18三体、21三体及神经管缺陷（NTD）等的高风险人数及产前诊断证实的染色体异常人数，统计唐氏筛查及无创基因检测的费用。结果：无创基因检测的高风险人数明显低于早、中期唐氏筛查，无创基因检测的诊断准确率明显高于早、中期唐氏筛查，无创基因检测的诊断经费明显高于早、中期唐氏筛查，以上比较差异均有统计学意义（P<0.05）。结论：无创基因检测筛出率高，但费用高；虽然产前血清学筛查筛出率比无创基因检出率低，但其费用大大低于无创基因检测，其更适合大规模人群的筛查。
目的：分析近2年深圳市龍崗區免費產前篩查與產前診斷的情況，優化篩查方案和流程。方法：對深圳市龍崗區2012年11月-2013年7月3431例進行免費無創基因檢測孕婦和2014年3月-2015年2月23746例免費產前血清學篩查孕婦的資料進行分析，分彆統計各自篩查齣的13三體、18三體、21三體及神經管缺陷（NTD）等的高風險人數及產前診斷證實的染色體異常人數，統計唐氏篩查及無創基因檢測的費用。結果：無創基因檢測的高風險人數明顯低于早、中期唐氏篩查，無創基因檢測的診斷準確率明顯高于早、中期唐氏篩查，無創基因檢測的診斷經費明顯高于早、中期唐氏篩查，以上比較差異均有統計學意義（P<0.05）。結論：無創基因檢測篩齣率高，但費用高；雖然產前血清學篩查篩齣率比無創基因檢齣率低，但其費用大大低于無創基因檢測，其更適閤大規模人群的篩查。
목적：분석근2년심수시룡강구면비산전사사여산전진단적정황，우화사사방안화류정。방법：대심수시룡강구2012년11월-2013년7월3431례진행면비무창기인검측잉부화2014년3월-2015년2월23746례면비산전혈청학사사잉부적자료진행분석，분별통계각자사사출적13삼체、18삼체、21삼체급신경관결함（NTD）등적고풍험인수급산전진단증실적염색체이상인수，통계당씨사사급무창기인검측적비용。결과：무창기인검측적고풍험인수명현저우조、중기당씨사사，무창기인검측적진단준학솔명현고우조、중기당씨사사，무창기인검측적진단경비명현고우조、중기당씨사사，이상비교차이균유통계학의의（P<0.05）。결론：무창기인검측사출솔고，단비용고；수연산전혈청학사사사출솔비무창기인검출솔저，단기비용대대저우무창기인검측，기경괄합대규모인군적사사。
Objective:To analyze the situation of prenatal screening and prenatal diagnosis for free in Longgang district of Shenzhen city in order to optimize the scheme and process of the screening.Method:The date of 3431 pregnant women who received noninvasive genetic testing for free from November 2011 to July 2013 and 23 746 pregnant women who received prenatal screening for free from March 2014 to February 2015 were analyzed,they were all from Longgang district of Shenzhen city. The numbers of pregnant women with high risk of trisomy 13,trisomy 18,trisomy 21 and NTD were recorded.The number of pregnant women who were diagnosed with chromosome abnormality by prenatal diagnosis was recorded too.Recording the costs of noninvasive genetic testing and down’s syndrome screening.Result:The number of people who were detected with high risk by noninvasive genetic testing was lower than that by down’s syndrome screening of early and middle stage,the accuracy rate and funds of diagnosis with noninvasive genetic testing was higher than those with down’s syndrome screening of early and middle stage,the differences above were all statistically significant(P<0.05).Conclusion:The screen out rate of noninvasive genetic testing is high,but its cost is high too.Although the screen out rate of prenatal serological screening is lower than that of the noninvasive genetic testing,but its cost is much lower than that of the noninvasive genetic testing,it is more suitable for the screening of large population.
