中国药物警戒
中國藥物警戒
중국약물경계
CHINESE JOURNAL OF PHARMACOVIGILANCE
2015年
8期
462-463
,共2页
牛蒡子苷元%上下法%急性毒性
牛蒡子苷元%上下法%急性毒性
우방자감원%상하법%급성독성
arctigenin%Up-and-Down Procedure%acute toxicity
目的：通过上下法（UDP）观察牛蒡子苷元注射液大鼠静脉注射及皮下注射毒性反应。方法 UDP 试验分静脉注射和皮下注射两组，根据 AOT425 StatPgm 设定程序进行试验。健康 SD 大鼠40只，各组20只。结果静脉注射 LD50为8.9 mg·kg-1，95%置信区间6.6～17.5 g·kg-1，皮下注射 LD50为227.3 mg·kg-1，95%置信区间166.3～348 mg·kg-1。结论牛蒡子苷元注射液静脉注射毒性较大，皮下注射较为安全。
目的：通過上下法（UDP）觀察牛蒡子苷元註射液大鼠靜脈註射及皮下註射毒性反應。方法 UDP 試驗分靜脈註射和皮下註射兩組，根據 AOT425 StatPgm 設定程序進行試驗。健康 SD 大鼠40隻，各組20隻。結果靜脈註射 LD50為8.9 mg·kg-1，95%置信區間6.6～17.5 g·kg-1，皮下註射 LD50為227.3 mg·kg-1，95%置信區間166.3～348 mg·kg-1。結論牛蒡子苷元註射液靜脈註射毒性較大，皮下註射較為安全。
목적：통과상하법（UDP）관찰우방자감원주사액대서정맥주사급피하주사독성반응。방법 UDP 시험분정맥주사화피하주사량조，근거 AOT425 StatPgm 설정정서진행시험。건강 SD 대서40지，각조20지。결과정맥주사 LD50위8.9 mg·kg-1，95%치신구간6.6～17.5 g·kg-1，피하주사 LD50위227.3 mg·kg-1，95%치신구간166.3～348 mg·kg-1。결론우방자감원주사액정맥주사독성교대，피하주사교위안전。
Objective To study the acute toxicity of arctigenin injection in rats by Up-and-Down Procedure(UDP). Methods The UDP test includes intravenous injection group and subcutaneous injection group, according to the AOT425 StatPgm administration. 40 healthy SD rats were divided into two groups, 20 each. Results LD50 of intra-venous injection group is 8.9 mg·kg -1, the 95% confidence interval is 6.6~17.5 mg·kg -1. LD50 of subcutaneous injection group is 227.3 mg·kg -1, the 95% confidence interval is 166.3~348 mg·kg -1. Conclusion In this study, arctigenin intravenous injection has greater toxicity, subcutaneous injection is relatively safe.
