CAJ | 학술논문

目的：探讨牛磺酸联合维生素E治疗非酒精性脂肪性肝病的疗效和安全性。方法选取2012年6月~2013年6月我院门诊经B超等检查诊断为非酒精性脂肪性肝病患者17例,用牛磺酸(2.0 g/次,3次/d,餐后服用)联合维生素E(100 mg/次,3次/d),疗程12周,治疗前后做肝功能、三酰甘油、血糖、血清总胆固醇、B超或CT检查。结果治疗后患者ALT、AST、GGT、总胆固醇、三酰甘油和空腹血糖显著降低,差异有统计学意义(P<0.05),B超或CT检查发现脂肪肝程度得到一定改善,治疗期间患者无不良反应。结论牛磺酸联合维生素E治疗非酒精性脂肪性肝病安全有效,且价廉,值得推广。
목적：탐토우광산연합유생소E치료비주정성지방성간병적료효화안전성。방법선취2012년6월~2013년6월아원문진경B초등검사진단위비주정성지방성간병환자17례,용우광산(2.0 g/차,3차/d,찬후복용)연합유생소E(100 mg/차,3차/d),료정12주,치료전후주간공능、삼선감유、혈당、혈청총담고순、B초혹CT검사。결과치료후환자ALT、AST、GGT、총담고순、삼선감유화공복혈당현저강저,차이유통계학의의(P<0.05),B초혹CT검사발현지방간정도득도일정개선,치료기간환자무불량반응。결론우광산연합유생소E치료비주정성지방성간병안전유효,차개렴,치득추엄。
Objective To explore the efficacy and security of taurine combined with vitamin E in treating non-alcoholic fatty liver disease. Methods 17 cases diagnosed via inspections like B ultrasound as non-alcoholic fatty liver disease from June 2012 to June 2013 in outpatient department of our hospital were selected.For treatment,taurine was taken (2 g/times,3 times/d,after meal taking),combined with vitamin E (100 mg/times,3 times/d) for treatment course of 12 weeks,and liver function,triglyceride,blood sugar,serum total cholesterol and B ultrasound or CT were tested before and after treatment. Results After the treatment with taurine combined with vitamin E,ALT,AST,GGT,total cholesterol,total cholesterol and fasting blood-glucose levels of patients were obviously decreased,with statistical difference(P<0.05),The degree of fatty liver was found to be improved to a certain extent though B altrasound or CT test,without obvious ad-verse reactions and obvious toxic and side effects during treatment. Conclusion Taurine combined with vitamin E in treating non-alcoholic fatty liver disease is safe and effective,which is inexpensive and worthy of promtion.