CAJ | 학술논문

系统性红斑狼疮（ systemic lupus erythematosus， SLE）是一种慢性多系统复发性自身免疫性疾病，严重危害人类健康。狼疮动物模型对于研究SLE的病因、发病机制和治疗具有重要意义。本文对各种狼疮动物模型进行评述和比较，以期探讨各种模型的优缺点，为研究者在寻找特定的致病机制、开发针对性的干预措施以及更具潜力的治疗药物过程中选择合适的模型提供参考。
계통성홍반랑창（ systemic lupus erythematosus， SLE）시일충만성다계통복발성자신면역성질병，엄중위해인류건강。랑창동물모형대우연구SLE적병인、발병궤제화치료구유중요의의。본문대각충랑창동물모형진행평술화비교，이기탐토각충모형적우결점，위연구자재심조특정적치병궤제、개발침대성적간예조시이급경구잠력적치료약물과정중선택합괄적모형제공삼고。
Systemic lupus erythematosus ( SLE) is a chronic multisystem relapsing-remitting autoimmune disease, which affects human health seriously.There are numerous animal models that have long been employed in an effort to un-derstand the mechanism and treatment of SLE.Animal models of SLE were reviewed and compared in this paper, to provide references for the researchers to choose appropriate models for studying specific pathogenic mechanism and diagnostic crite-ria, searching for targeted treatment interventions and developing potential therapeutic drugs.