CAJ | 학술논문

目的：分析术前使用序贯化放疗与单纯放疗治疗局部晚期宫颈癌的近期疗效。方法：选取2011年1月-2014年3月在本院确诊的局部晚期宫颈癌患者62例作为研究对象，采用随机数字表法分为两组，序贯组34例行序贯化放疗，对照组28例行单纯术前放疗；放疗后MRI评价疗效，符合条件者放疗后2~3周行开腹宫颈癌根治术，观察比较两组治疗疗效、毒副反应及术中、术后情况。结果：序贯组的有效率及手术率均高于对照组，比较差异有统计学意义（P<0.05）。序贯组骨髓抑制及胃肠道反应发生情况多于对照组，比较差异均有统计学意义（P<0.05）；两组放射性直肠、膀胱炎症及皮肤反应发生情况比较差异无统计学性意义（P>0.05）；序贯组的手术时间、术中出血量、术后淋巴结转移及脉管癌栓情况均优于对照组，比较差异有统计学意义（P<0.05）。结论：术前序贯化放疗后手术治疗局部晚期宫颈癌近期疗效确切，安全性高，值得进一步进行相关临床研究。
목적：분석술전사용서관화방료여단순방료치료국부만기궁경암적근기료효。방법：선취2011년1월-2014년3월재본원학진적국부만기궁경암환자62례작위연구대상，채용수궤수자표법분위량조，서관조34례행서관화방료，대조조28례행단순술전방료；방료후MRI평개료효，부합조건자방료후2~3주행개복궁경암근치술，관찰비교량조치료료효、독부반응급술중、술후정황。결과：서관조적유효솔급수술솔균고우대조조，비교차이유통계학의의（P<0.05）。서관조골수억제급위장도반응발생정황다우대조조，비교차이균유통계학의의（P<0.05）；량조방사성직장、방광염증급피부반응발생정황비교차이무통계학성의의（P>0.05）；서관조적수술시간、술중출혈량、술후림파결전이급맥관암전정황균우우대조조，비교차이유통계학의의（P<0.05）。결론：술전서관화방료후수술치료국부만기궁경암근기료효학절，안전성고，치득진일보진행상관림상연구。
Objective:To analyze the recent effect of sequential neoadjuvant chemoradiotherapy and radiotherapy in the treatment of local advanced cervical carcinoma before operation.Method:62 patients who were diagnosed with local advanced cervical carcinoma in our hospital from January 2011 to March 2014 were selected and randomly divided into two groups.34 patients in the sequential group were treated by sequential neoadjuvant chemoradiotherapy.The other 28 patients in the control group were just treated by radiotherapy.The effects were evaluated by MRI after the radiotherapy .Then patients in line with the conditions of radical hysterectomy got surgery 2 to 3 weeks after the radiotherapy.The treatment effect,toxic and side effects,the situation during and after the operation of the two groups were observed and compared.Result:The effective rate and surgery rate of the sequential group were higher than those of the control group,the differences were statistically significant(P<0.05).The occurrence rates of bone marrow suppression and gastrointestinal reaction in the sequential group were higher than those in the control group,the differences were statistically significant(P<0.05).There were no statistical differences in the occurrence of redioactive rectum,bladder inflammation and skin reaction between the two groups(P>0.05).Compared with the control group, the sequential group had less operation time,less amount of bleeding,lower rate of postoperative lymph node metastasis and vessel carcinoma embolus,the differences were statistically significant(P<0.05). Conclusion:The recent effect of sequential neoadjuvant chemoradiotherapy before local advanced cervical carcinoma operation is exact.This treatment is worth further clinical studying.