CAJ | 학술논문

目的：探讨术前使用右美托咪定对老年前列腺术后早期认知功能的影响。方法选取本院2013年10月~2014年12月收治的64例老年前列腺患者作为研究对象，随机分成实验组和对照组，各32例。实验组在老年前列腺患者进行手术前泵注右美托咪定，对照组泵注等量的生理食盐水，比较两组的MMSE评分、术后认知功能障碍发生率及MAP和HR水平。结果实验组术后5 h和1 d的MMSE评分显著高于对照组，差异有统计学意义(P<0.05)。实验组的术后认知功能障碍发生率显著低于对照组，差异有统计学意义(P<0.05)。实验组术后的MAP、HR水平显著低于对照组，差异有统计学意义(P<0.05)。结论在老年患者手术前使用右美托咪定，可以有效降低术后认知功能障碍发生率。
목적：탐토술전사용우미탁미정대노년전렬선술후조기인지공능적영향。방법선취본원2013년10월~2014년12월수치적64례노년전렬선환자작위연구대상，수궤분성실험조화대조조，각32례。실험조재노년전렬선환자진행수술전빙주우미탁미정，대조조빙주등량적생리식염수，비교량조적MMSE평분、술후인지공능장애발생솔급MAP화HR수평。결과실험조술후5 h화1 d적MMSE평분현저고우대조조，차이유통계학의의(P<0.05)。실험조적술후인지공능장애발생솔현저저우대조조，차이유통계학의의(P<0.05)。실험조술후적MAP、HR수평현저저우대조조，차이유통계학의의(P<0.05)。결론재노년환자수술전사용우미탁미정，가이유효강저술후인지공능장애발생솔。
Objective To explore the influence of preoperative application of dexmedetomidine on early postoperative cognitive dysfunction (POCD) for elderly patients after prostate surgery. Methods 64 elderly patients with prostate dis-ease in our hospital from October 2013 to December 2014 were selected and randomly divided into the experiment group and the control group,32 cases in each group.The experiment group was pumped with dexmedetomidine before surgery for elderly patients with prostate disease,the control group was pumped with the equal amount of normal saline. The score of MMSE,the incidence rate of POCD,the level of MAP and HR in two groups was compared. Results The score of MMSE after operation at 5 hours and 1 day in the experiment group was higher than that in the control group, with significant difference (P<0.05).The incidence rate of POCD in the experiment group was lower than that in the control group,with significant difference (P<0.05).The level of MAP and HR in the experiment group was lower than that in the control group,with significant difference (P<0.05). Conclusion Dexmedetomidine applied before surgery for elderly patients can effective reduce the incidence rate of POCD.