中西医结合心血管病电子杂志
中西醫結閤心血管病電子雜誌
중서의결합심혈관병전자잡지
Cardiovascular Disease Journal of Integrated Traditional Chinese and Western Medicine (Electronic)
2015年
9期
81-83
,共3页
vWF%vWF-cp%胎盘源性子痫前期%妊娠期高血压疾病%免疫组织化学
vWF%vWF-cp%胎盤源性子癇前期%妊娠期高血壓疾病%免疫組織化學
vWF%vWF-cp%태반원성자간전기%임신기고혈압질병%면역조직화학
vWF%vWF-cp%The source of placenta in preeclampsia%Hypertensive disorders complicating pregnancy%Immunohistochemistry
目的：探讨血管性血友病因子（vWF）与血管性血友病因子裂解酶（vWF-cp）在妊娠期高血压疾病胎盘组织中的表达及意义。方法采用免疫组织化学方法检测妊娠期高血压疾病患者90例（妊娠期高血压组、轻度子痫前期组、重度子痫前期组，各30例）与30名正常妊娠产妇胎盘组织中vWF和vWF-cp的表达。结果妊娠期高血压组、轻度子痫前期组、重度子痫前期组对比正常妊娠组，vWF在胎盘组织的表达强度显著升高，差异有统计学意义（P＜0.05）；vWF-cp在胎盘组织里的表达强度显著降低，差异有统计学意义（P＜0.05）。结论妊娠期高血压疾病中vWF及vWF-cp的表达水平变化最终导致血管内皮细胞脱落产生胎盘源性改变，从而与妊娠期高血压疾病的发病与病情有关。
目的：探討血管性血友病因子（vWF）與血管性血友病因子裂解酶（vWF-cp）在妊娠期高血壓疾病胎盤組織中的錶達及意義。方法採用免疫組織化學方法檢測妊娠期高血壓疾病患者90例（妊娠期高血壓組、輕度子癇前期組、重度子癇前期組，各30例）與30名正常妊娠產婦胎盤組織中vWF和vWF-cp的錶達。結果妊娠期高血壓組、輕度子癇前期組、重度子癇前期組對比正常妊娠組，vWF在胎盤組織的錶達彊度顯著升高，差異有統計學意義（P＜0.05）；vWF-cp在胎盤組織裏的錶達彊度顯著降低，差異有統計學意義（P＜0.05）。結論妊娠期高血壓疾病中vWF及vWF-cp的錶達水平變化最終導緻血管內皮細胞脫落產生胎盤源性改變，從而與妊娠期高血壓疾病的髮病與病情有關。
목적：탐토혈관성혈우병인자（vWF）여혈관성혈우병인자렬해매（vWF-cp）재임신기고혈압질병태반조직중적표체급의의。방법채용면역조직화학방법검측임신기고혈압질병환자90례（임신기고혈압조、경도자간전기조、중도자간전기조，각30례）여30명정상임신산부태반조직중vWF화vWF-cp적표체。결과임신기고혈압조、경도자간전기조、중도자간전기조대비정상임신조，vWF재태반조직적표체강도현저승고，차이유통계학의의（P＜0.05）；vWF-cp재태반조직리적표체강도현저강저，차이유통계학의의（P＜0.05）。결론임신기고혈압질병중vWF급vWF-cp적표체수평변화최종도치혈관내피세포탈락산생태반원성개변，종이여임신기고혈압질병적발병여병정유관。
Objective Study of vWF and vWF-cp expression and significance in placental of hypertensive disorder in pregnancy.Methods Detection of 90 cases of gestational hypertension group by munohistochemical method (30 cases of gestational hypertension; 30 cases of mild preeclampsia; 30 cases of severe preeclampsia) and 30 cases of normal pregnancy the expression of vWF and vWF-cp in the placenta. Results Gestational hypertension;30 cases of mild preeclampsia; 30 cases of severe preeclampsia compared with normal pregnancy group, the expression intensity of vWF in placenta in significantly increased (P<0.05), with a statistically significant difference between the groups; the expression intensity of vWF-cp in placenta tissue was significantly lower (P<0.05), with a statistically significant difference between the groups.Conclusion The expression levels of vWF and vWF-cp in gestational hypertension disease in patients with damaged vascular endothelial cells in the placenta, the placenta is small, resulting in the pathogenesis of vascular endothelial cell loss hypertension induced apoptosis of placenta derived cells and pregnancy related disease.
