中国实用眼科杂志
中國實用眼科雜誌
중국실용안과잡지
CHINESE JOURNAL OF PRACTICAL OPHTHALMOLOGY
2015年
6期
603-606
,共4页
增殖期糖尿病视网膜病变%糖尿病肾病%危险因素
增殖期糖尿病視網膜病變%糖尿病腎病%危險因素
증식기당뇨병시망막병변%당뇨병신병%위험인소
Proliferative diabetic retinopathy%Diabetic nephropathy%Risk factor
目的 观察无糖尿病肾病(DN)增殖期糖尿病视网膜病变(PDR)患者的危险因素.方法 回顾性临床病例研究.对2010年1月至2014年6月在内蒙古民族大学附属医院内分泌科选取PDR患者193例,根据尿蛋白/肌酐比值(ACR)分为无DN的PDR组(A组),既有DN又有PDR组(B组).采用问卷调查、生化指标检查和眼科专科检查进行比较和多元线性回归分析进行研究.结果 193例PDR患者中,A组86例(44.56％),B组107例(55.44％).A组LDL-C及TC/HDL明显高于B组,差异有统计学意义(P =0.001,P＜0.01),而TG、DBP、SBP明显低于B组,差异有统计学意义(P ＜0.01;P=0.007;P=0.01).A组有DM家族史患者与B组比较差异有统计学意义(48例vs30例,Z=11.94,P=0.03).A组DME的发生率比B组高(P =0.021),尤其是重度DME差异有统计学意义(P =0.001).Logistic回归分析结果显示DME、家族史、TC/HDL、LDL-C是无DN的PDR患者的独立危险因素.结论 LDL-C、TC/HDL、DME、家族史是独立于糖尿病微血管病变的PDR的危险因素.
目的 觀察無糖尿病腎病(DN)增殖期糖尿病視網膜病變(PDR)患者的危險因素.方法 迴顧性臨床病例研究.對2010年1月至2014年6月在內矇古民族大學附屬醫院內分泌科選取PDR患者193例,根據尿蛋白/肌酐比值(ACR)分為無DN的PDR組(A組),既有DN又有PDR組(B組).採用問捲調查、生化指標檢查和眼科專科檢查進行比較和多元線性迴歸分析進行研究.結果 193例PDR患者中,A組86例(44.56％),B組107例(55.44％).A組LDL-C及TC/HDL明顯高于B組,差異有統計學意義(P =0.001,P＜0.01),而TG、DBP、SBP明顯低于B組,差異有統計學意義(P ＜0.01;P=0.007;P=0.01).A組有DM傢族史患者與B組比較差異有統計學意義(48例vs30例,Z=11.94,P=0.03).A組DME的髮生率比B組高(P =0.021),尤其是重度DME差異有統計學意義(P =0.001).Logistic迴歸分析結果顯示DME、傢族史、TC/HDL、LDL-C是無DN的PDR患者的獨立危險因素.結論 LDL-C、TC/HDL、DME、傢族史是獨立于糖尿病微血管病變的PDR的危險因素.
목적 관찰무당뇨병신병(DN)증식기당뇨병시망막병변(PDR)환자적위험인소.방법 회고성림상병례연구.대2010년1월지2014년6월재내몽고민족대학부속의원내분비과선취PDR환자193례,근거뇨단백/기항비치(ACR)분위무DN적PDR조(A조),기유DN우유PDR조(B조).채용문권조사、생화지표검사화안과전과검사진행비교화다원선성회귀분석진행연구.결과 193례PDR환자중,A조86례(44.56％),B조107례(55.44％).A조LDL-C급TC/HDL명현고우B조,차이유통계학의의(P =0.001,P＜0.01),이TG、DBP、SBP명현저우B조,차이유통계학의의(P ＜0.01;P=0.007;P=0.01).A조유DM가족사환자여B조비교차이유통계학의의(48례vs30례,Z=11.94,P=0.03).A조DME적발생솔비B조고(P =0.021),우기시중도DME차이유통계학의의(P =0.001).Logistic회귀분석결과현시DME、가족사、TC/HDL、LDL-C시무DN적PDR환자적독립위험인소.결론 LDL-C、TC/HDL、DME、가족사시독립우당뇨병미혈관병변적PDR적위험인소.
Objective To analyze the risk factors of subjects with type 2 diabetes mellitus having proliferative retinopathy but no nephropathy.Methods A total of 193 cases of T2DM patients were selected and divided into two groups of having proliferative retinopathy but no nephropathy (group A) and having both retinopathy and nephropathy (group B).The questionnaire,biochemical test and ophthalmic testing were analyzed and multiple stepwise regrression were conducted.Results Of 193 subjects 86 were cases (Group A,44.56％),whilst 107 were controls (group B,55.44％).Group A had significantly higher LDL-C (P =0.001) and TC/HDL (P ＜0.001) and had lower TG (P ＜0.001),DBP (P =0.007),SBP (P =0.001).In group A,48 patients had diabetic family history while in group B 30 ones had (x2=11.94,P =0.03).The occurrence of diabetic macular edema of group A was significantly higher (P =0.021).DME,family history,LDL-C and TC/HDL were risk factors for subjects with type 2 diabetes mellitus having proliferative retinopathy but no nephropathy after Logistic regression analysis.Conclusions By analyzing factors associated with diabetic proliferative retinopathy rather than microvascular disease in general,our study provide evidence that DME,family history,LDL-C and TC/HDL are associated with diabetic proliferative retinopathy.
