微循环学杂志
微循環學雜誌
미순배학잡지
CHINESE JOURNAL OF MICROCIRCULATION
2015年
3期
38-41,44
,共5页
大黄通便颗粒%生大黄%重症急性胰腺炎%疗效
大黃通便顆粒%生大黃%重癥急性胰腺炎%療效
대황통편과립%생대황%중증급성이선염%료효
Rhubarb laxative granules%Rhubarb%Severe acute pancreatitis%Effect
目的：：比较大黄通便颗粒和生大黄协同常规方法治疗重症急性胰腺炎(SAP)的临床疗效。方法：前瞻性、连续性纳入74例 SAP 患者,随机分为生大黄治疗组(生大黄组,n=40)和大黄通便颗粒治疗组(大黄颗粒组, n=34)。在常规治疗基础上,生大黄组以生大黄泡水经鼻-空肠管灌入；大黄颗粒组以大黄通便颗粒悬液经鼻-空肠管灌入治疗,均2次/日,持续治疗一周后,比较两组患者血清淀粉酶(AMS)、血清脂肪酶(LPS)等指标恢复至正常参考范围所用时间及腹痛缓解时间、通便时间等的差异,比较两组患者治疗前后 Ranson 评分、CT 严重程度指数评分(CTSI 评分)、急性胰腺炎严重程度床边指数评分(BISAP 评分)、简化急性生理学评分(SAPSⅡ评分)、急性生理与慢性健康评分(APACHEⅡ评分)及临床疗效。结果：与生大黄组相比,大黄颗粒组患者脂联素(APN)、白细胞介素-6(IL-6)、降钙素原(PCT)、AMS 恢复至正常参考范围所用时间明显较短(P <0.05),初次排便时间较早(P <0.05)。两组治疗后 APACHEⅡ、CTSI、Ranson 三项量表评分均较同组治疗前降低(P <0.05),大黄颗粒组比生大黄组降低更明显(P <0.05)。大黄颗粒组患者临床有效率和总有效率明显高于生大黄组(P <0.05)。结论：大黄通便颗粒治疗 SAP 疗效优于生大黄。
目的：：比較大黃通便顆粒和生大黃協同常規方法治療重癥急性胰腺炎(SAP)的臨床療效。方法：前瞻性、連續性納入74例 SAP 患者,隨機分為生大黃治療組(生大黃組,n=40)和大黃通便顆粒治療組(大黃顆粒組, n=34)。在常規治療基礎上,生大黃組以生大黃泡水經鼻-空腸管灌入；大黃顆粒組以大黃通便顆粒懸液經鼻-空腸管灌入治療,均2次/日,持續治療一週後,比較兩組患者血清澱粉酶(AMS)、血清脂肪酶(LPS)等指標恢複至正常參攷範圍所用時間及腹痛緩解時間、通便時間等的差異,比較兩組患者治療前後 Ranson 評分、CT 嚴重程度指數評分(CTSI 評分)、急性胰腺炎嚴重程度床邊指數評分(BISAP 評分)、簡化急性生理學評分(SAPSⅡ評分)、急性生理與慢性健康評分(APACHEⅡ評分)及臨床療效。結果：與生大黃組相比,大黃顆粒組患者脂聯素(APN)、白細胞介素-6(IL-6)、降鈣素原(PCT)、AMS 恢複至正常參攷範圍所用時間明顯較短(P <0.05),初次排便時間較早(P <0.05)。兩組治療後 APACHEⅡ、CTSI、Ranson 三項量錶評分均較同組治療前降低(P <0.05),大黃顆粒組比生大黃組降低更明顯(P <0.05)。大黃顆粒組患者臨床有效率和總有效率明顯高于生大黃組(P <0.05)。結論：大黃通便顆粒治療 SAP 療效優于生大黃。
목적：：비교대황통편과립화생대황협동상규방법치료중증급성이선염(SAP)적림상료효。방법：전첨성、련속성납입74례 SAP 환자,수궤분위생대황치료조(생대황조,n=40)화대황통편과립치료조(대황과립조, n=34)。재상규치료기출상,생대황조이생대황포수경비-공장관관입；대황과립조이대황통편과립현액경비-공장관관입치료,균2차/일,지속치료일주후,비교량조환자혈청정분매(AMS)、혈청지방매(LPS)등지표회복지정상삼고범위소용시간급복통완해시간、통편시간등적차이,비교량조환자치료전후 Ranson 평분、CT 엄중정도지수평분(CTSI 평분)、급성이선염엄중정도상변지수평분(BISAP 평분)、간화급성생이학평분(SAPSⅡ평분)、급성생리여만성건강평분(APACHEⅡ평분)급림상료효。결과：여생대황조상비,대황과립조환자지련소(APN)、백세포개소-6(IL-6)、강개소원(PCT)、AMS 회복지정상삼고범위소용시간명현교단(P <0.05),초차배편시간교조(P <0.05)。량조치료후 APACHEⅡ、CTSI、Ranson 삼항량표평분균교동조치료전강저(P <0.05),대황과립조비생대황조강저경명현(P <0.05)。대황과립조환자림상유효솔화총유효솔명현고우생대황조(P <0.05)。결론：대황통편과립치료 SAP 료효우우생대황。
Objective:To compare the effect of rhubarb laxative particles and rhubarb on the treatment of se-vere acute pancreatitis(SAP).Method:SAP patients included 74 cases with prospective and continuity,which were randomly divided into rhubarb laxative particles group (n=34)and rhubarb group (n=40).On the basis of routine treatment,rhubarb group with rhubarb soaked nasal-jejunal tube poured rhubarb laxative group nasal-jejunal tube poured.They were treated for one week.Two groups were compared serum amylase (AMS),serum lipase (LPS) to the required recovery time and the time of abdominal pain,constipation times the normal reference values.Two groups of patients before and after treatment were campared with Ranson score,CTSI score,BISAP score,SAPSⅡscore,APACHEⅡ score and clinical efficacy.Results:Compared with rhubarb group,patients in rhubarb laxative particle group APN,IL-6,PCT,AMS returned to normal reference range was significantly shorter (P <0.05),the first defecation time earlier (P <0.05).After treatment APACHEⅡ,CTSI,Ranson three scale scores were lower than before treatment (P <0.05 ),rhubarb particles group were decreased more significantly (P <0.05 ).Conclu-sion:Rhubarb laxative is better than rhubarb with the effect of particle therapy in SAP.
