微循环学杂志
微循環學雜誌
미순배학잡지
CHINESE JOURNAL OF MICROCIRCULATION
2015年
3期
51-54
,共4页
高级别前列腺上皮内瘤%血浆纤维蛋白原%辅助诊断
高級彆前列腺上皮內瘤%血漿纖維蛋白原%輔助診斷
고급별전렬선상피내류%혈장섬유단백원%보조진단
High-grade prostatic intraepithelial neoplasia%Plasma fibrinogen%Assisted diagnosis
目的::探讨高级别前列腺上皮内瘤(HGPIN)患者血浆纤维蛋白原(Fib)水平变化及其临床意义。方法:111例良性前列腺增生(BPH)患者(BPH 组)、55例 HGPIN 患者(HGPIN 组)、61例前列腺癌(PCa)患者(PCa组),采用免疫比浊法检测各组血浆 Fib 浓度,采用双夹心免疫法及化学发光法检测 HGPIN 组血清前列腺特异性抗原(PSA,包括 tPSA 和 cPSA)水平,统计学分析各组 Fib 水平差异及 HGPIN 组 Fib 与 PSA 的相关性。以病理诊断为金标准、评价 Fib 对 HGPIN 的诊断价值。结果:三组患者血浆 Fib 水平中位数分别为2.55g/L,3.22g/L 和4.09g/L,HGPIN 组和 PCa 组显著高于 BPH 组(P <0.01),PCa 组又高于 HGPIN 组,差异均有统计学意义(P <0.01)。HGPIN 组血浆 Fib 水平与血清 tPSA、cPSA 水平呈显著正相关(r =0.304、0.334,P <0.05)。血浆 Fib 诊断HGPIN 的敏感度为23.64%,特异度为93.69%,误诊率为6.31%,漏诊率为76.36%。结论:HGPIN 患者血浆 Fib水平升高,可以作为 HGPIN 患者辅助诊断的参考指标。
目的::探討高級彆前列腺上皮內瘤(HGPIN)患者血漿纖維蛋白原(Fib)水平變化及其臨床意義。方法:111例良性前列腺增生(BPH)患者(BPH 組)、55例 HGPIN 患者(HGPIN 組)、61例前列腺癌(PCa)患者(PCa組),採用免疫比濁法檢測各組血漿 Fib 濃度,採用雙夾心免疫法及化學髮光法檢測 HGPIN 組血清前列腺特異性抗原(PSA,包括 tPSA 和 cPSA)水平,統計學分析各組 Fib 水平差異及 HGPIN 組 Fib 與 PSA 的相關性。以病理診斷為金標準、評價 Fib 對 HGPIN 的診斷價值。結果:三組患者血漿 Fib 水平中位數分彆為2.55g/L,3.22g/L 和4.09g/L,HGPIN 組和 PCa 組顯著高于 BPH 組(P <0.01),PCa 組又高于 HGPIN 組,差異均有統計學意義(P <0.01)。HGPIN 組血漿 Fib 水平與血清 tPSA、cPSA 水平呈顯著正相關(r =0.304、0.334,P <0.05)。血漿 Fib 診斷HGPIN 的敏感度為23.64%,特異度為93.69%,誤診率為6.31%,漏診率為76.36%。結論:HGPIN 患者血漿 Fib水平升高,可以作為 HGPIN 患者輔助診斷的參攷指標。
목적::탐토고급별전렬선상피내류(HGPIN)환자혈장섬유단백원(Fib)수평변화급기림상의의。방법:111례량성전렬선증생(BPH)환자(BPH 조)、55례 HGPIN 환자(HGPIN 조)、61례전렬선암(PCa)환자(PCa조),채용면역비탁법검측각조혈장 Fib 농도,채용쌍협심면역법급화학발광법검측 HGPIN 조혈청전렬선특이성항원(PSA,포괄 tPSA 화 cPSA)수평,통계학분석각조 Fib 수평차이급 HGPIN 조 Fib 여 PSA 적상관성。이병리진단위금표준、평개 Fib 대 HGPIN 적진단개치。결과:삼조환자혈장 Fib 수평중위수분별위2.55g/L,3.22g/L 화4.09g/L,HGPIN 조화 PCa 조현저고우 BPH 조(P <0.01),PCa 조우고우 HGPIN 조,차이균유통계학의의(P <0.01)。HGPIN 조혈장 Fib 수평여혈청 tPSA、cPSA 수평정현저정상관(r =0.304、0.334,P <0.05)。혈장 Fib 진단HGPIN 적민감도위23.64%,특이도위93.69%,오진솔위6.31%,루진솔위76.36%。결론:HGPIN 환자혈장 Fib수평승고,가이작위 HGPIN 환자보조진단적삼고지표。
Objective:To detect the plasma level of fibrinogen (Fib)in patients with high-grade prostatic in-traepithelial neoplasia(HGPIN)and its clinical significance.Method:The study included 1 1 1 cases of benign prostat-ic hyperplasia (BPH)patients,55 patients with HGPIN and 61 cases of patients with prostate cancer (PCa).The concentration of plasma Fib was detected using immunoturbidimetry and serum prostate specific antigen (PSA)in-cluding tPSA and cPSA were detected using double sandwich immune method and chemical luminescence method. Then analysis the difference of Fib in each group and the correlation of Fib and PSA in HGPIN group with statistical method.Results:The median of the plasma level of Fib in group BPH,HGPIN and PCa were 2.55g/L,3.22g/L,4. 09g/L.The plasma Fib was significantly increased in patients with HGPIN and PCa compared to patients with BPH (P <0.01).The plasma Fib was higher in patients with PCa than those with HGPIN(P <0.01).The level of plas-ma Fib was significant positively correlated with serum PSA in HGPIN patients (P <0.05).When plasma Fib was used to diagnose HGPIN,the sensitivity,specificity,mistake diagnostic rate and omission diagnostic rate were 23. 64%,93.69%,6.31%,76.36%.Conclusion:Plasma Fib is significantly increased in patients with HGPIN.Thus, it might be a diagnostic indicator for HGPIN patients.