CAJ | 학술논문

目的：观察中药消脂护肝胶囊对非酒精性脂肪肝(NAFLD)大鼠的治疗作用，探讨其可能的作用机制。方法采用复合因素复制大鼠NAFLD模型，选取健康雄性SD大鼠72只，按体重随机分为6组，每组12只院空白对照组(简称空白组)、模型对照组(模型组)、东宝肝泰对照组(东宝组)、消脂护肝胶囊高剂量组(消高组)、消脂护肝胶囊中剂量组(消中组)、消脂护肝胶囊低剂量组(消低组)。观察各组大鼠的血糖、血清瘦素(LP)、胰岛素，丙氨酸氨基转移酶(ALT)、天冬氨酸氨基转移酶(AST)；血清总胆固醇(TC)、三酰甘油((TG)；肝组织病理学。结果与模型组比较，消高组、消中组的LP及胰岛素抵抗(IR)指数均明显下降(P<0.01)；与模型组比较，消高组(P<0.01)、消中组(P<0.05)的肝细胞脂变率明显降低。结论消脂护肝胶囊能降低血清LP水平，改善IR状态，对NAFLD有良好的防治作用。
목적：관찰중약소지호간효낭대비주정성지방간(NAFLD)대서적치료작용，탐토기가능적작용궤제。방법채용복합인소복제대서NAFLD모형，선취건강웅성SD대서72지，안체중수궤분위6조，매조12지원공백대조조(간칭공백조)、모형대조조(모형조)、동보간태대조조(동보조)、소지호간효낭고제량조(소고조)、소지호간효낭중제량조(소중조)、소지호간효낭저제량조(소저조)。관찰각조대서적혈당、혈청수소(LP)、이도소，병안산안기전이매(ALT)、천동안산안기전이매(AST)；혈청총담고순(TC)、삼선감유((TG)；간조직병이학。결과여모형조비교，소고조、소중조적LP급이도소저항(IR)지수균명현하강(P<0.01)；여모형조비교，소고조(P<0.01)、소중조(P<0.05)적간세포지변솔명현강저。결론소지호간효낭능강저혈청LP수평，개선IR상태，대NAFLD유량호적방치작용。
Objective To observe the treatment role of Xiaozhihugan Capsule of Chinese medicine for rats with nonal-coholic fatty liver disease (NAFLD),and to discuss its possible mechanism of action. Methods NAFLD model of rate was copied using composite factor.72 healthy and male rats were divided into 6 groups,and there were 12 rats in each group:blank control group (blank group),model control group (model group),dongbaogantai control group (dongbao group), Xiaozhi Hugan Capsule high dose group (Xiaogao group), Xiaozhi Hugan Capsule middle dose group (Xiaozhong group), Xiaozhi Hugan capsule low dose group (Xiaodi group).Blood sugar,serum leptin (LP),insulin;serum alanine aminotrans-ferase (ALT),aspartate aminotransferase (AST);serum total cholesterol (TC),triglyceride (TG);liver tissue pathology was observed of rats in each group respectively. Results Compared with model group,LP and insulin resistance (IR) index in Xiaogao group and Xiaozhong group was obviously decreased respectively (P<0.01);Compared with model group,fat change rate of liver cell in Xiaogao group (P<0.01) and Xiaozhong group (P<0.05) was obviously decreased respectively. Con-clusion Xiaozhihugan Capsule can reduce serum LP level,improve insulin resistance,and has good preventive and thera-peutic role for NAFLD.