CAJ | 학술논문

目的：优化提取新健胃包芯片中大黄总蒽醌类成分的影响因素,完善质量标准,加强产品质量控制。方法对提取方式进行单因素考察,对提取温度、时间,水解时间等影响因素进行优化处理,以HPLC法测定制剂中大黄总蒽醌类成分含量为质控指标。结果新健胃包芯片制剂中最佳提取条件为75℃甲醇回流提取1.5 h,8%盐酸酸化后,再提取2.0 h,有效成分的提取率最高,总蒽醌类成分最稳定。结论该方法稳定可行,可以作为该制剂的质量控制方法。
목적：우화제취신건위포심편중대황총은곤류성분적영향인소,완선질량표준,가강산품질량공제。방법대제취방식진행단인소고찰,대제취온도、시간,수해시간등영향인소진행우화처리,이HPLC법측정제제중대황총은곤류성분함량위질공지표。결과신건위포심편제제중최가제취조건위75℃갑순회류제취1.5 h,8%염산산화후,재제취2.0 h,유효성분적제취솔최고,총은곤류성분최은정。결론해방법은정가행,가이작위해제제적질량공제방법。
Objective To optimize the extraction factors of Rhubarb total anthraquinones ingredients in Xin Jianwei chip tablet, and to improve the quality standards to strengthen the quality control of products. Methods The extractive method was conducted a single-factor investigation,and the extraction temperature and time,and hydrolysis time were optimizated.The content of Rhubarb total anthraquinones ingredients in preparation used as an indicator of quality con-trol was determined by HPLC method. Results The optimal extractive conditions of preparation were determined as fol-lows:reflux extraction of methanol at 75℃ for 1.5 h,then,8% hydrochloric acid for acidification,and continued to extract for 2.0 h,at this time,the extraction rate of active components was the highest,and total anthraquinones ingredients were most stable. Conclusion This method is stable and feasible,and it can be used as quality control method of the prepara-tion.