中国性科学
中國性科學
중국성과학
THE CHINESE JOURNAL OF HUMAN SEXUALITY
2015年
8期
16-18
,共3页
宫颈鳞癌%同步放化疗%顺铂%氟尿嘧啶
宮頸鱗癌%同步放化療%順鉑%氟尿嘧啶
궁경린암%동보방화료%순박%불뇨밀정
Squamous carcinoma of the cervix%Concurrent chemoradiotherapy%Cisplatin%Flu-orouracil
目的:探讨Ⅰb2~Ⅳa 期宫颈鳞癌患者同步放化疗中两种含铂化疗方案的疗效和安全性。方法:病例选自2010年2月至2013年4月我院的80例Ⅰb2~Ⅳa 期宫颈鳞癌的患者。在患者知情同意的情况下,按照随机数表法,将所有患者均分为观察组和对照组。对照组采用顺铂同步放疗的方案对患者进行治疗,观察组则采用氟尿嘧啶联合顺铂化疗同步放疗的方案对患者进行治疗。治疗后,评定分析两组患者的近期疗效和不良反应,并随访调查患者的远期疗效。结果:治疗3个月后,发现观察组治疗的总有效率为85.00%,对照组的总有效率为77.50%,观察组患者总有效率明显高于对照组(P <0.05)。随访调查3年后,发现观察组患者的3年生存率(87.50%)明显高于对照组(67.50%),两组比较有统计学意义(χ2=4.5878,P =0.0322);局部复发率和远处转移率(20.00%;17.50%)均明显低于对照组(42.50%;37.50%),两组比较有显著性差异(P <0.05)。结论:氟尿嘧啶联合顺铂化疗同步放疗的方案治疗Ⅰb2~Ⅳa 期宫颈鳞癌患者疗效显著,安全性高,值得临床推广应用。
目的:探討Ⅰb2~Ⅳa 期宮頸鱗癌患者同步放化療中兩種含鉑化療方案的療效和安全性。方法:病例選自2010年2月至2013年4月我院的80例Ⅰb2~Ⅳa 期宮頸鱗癌的患者。在患者知情同意的情況下,按照隨機數錶法,將所有患者均分為觀察組和對照組。對照組採用順鉑同步放療的方案對患者進行治療,觀察組則採用氟尿嘧啶聯閤順鉑化療同步放療的方案對患者進行治療。治療後,評定分析兩組患者的近期療效和不良反應,併隨訪調查患者的遠期療效。結果:治療3箇月後,髮現觀察組治療的總有效率為85.00%,對照組的總有效率為77.50%,觀察組患者總有效率明顯高于對照組(P <0.05)。隨訪調查3年後,髮現觀察組患者的3年生存率(87.50%)明顯高于對照組(67.50%),兩組比較有統計學意義(χ2=4.5878,P =0.0322);跼部複髮率和遠處轉移率(20.00%;17.50%)均明顯低于對照組(42.50%;37.50%),兩組比較有顯著性差異(P <0.05)。結論:氟尿嘧啶聯閤順鉑化療同步放療的方案治療Ⅰb2~Ⅳa 期宮頸鱗癌患者療效顯著,安全性高,值得臨床推廣應用。
목적:탐토Ⅰb2~Ⅳa 기궁경린암환자동보방화료중량충함박화료방안적료효화안전성。방법:병례선자2010년2월지2013년4월아원적80례Ⅰb2~Ⅳa 기궁경린암적환자。재환자지정동의적정황하,안조수궤수표법,장소유환자균분위관찰조화대조조。대조조채용순박동보방료적방안대환자진행치료,관찰조칙채용불뇨밀정연합순박화료동보방료적방안대환자진행치료。치료후,평정분석량조환자적근기료효화불량반응,병수방조사환자적원기료효。결과:치료3개월후,발현관찰조치료적총유효솔위85.00%,대조조적총유효솔위77.50%,관찰조환자총유효솔명현고우대조조(P <0.05)。수방조사3년후,발현관찰조환자적3년생존솔(87.50%)명현고우대조조(67.50%),량조비교유통계학의의(χ2=4.5878,P =0.0322);국부복발솔화원처전이솔(20.00%;17.50%)균명현저우대조조(42.50%;37.50%),량조비교유현저성차이(P <0.05)。결론:불뇨밀정연합순박화료동보방료적방안치료Ⅰb2~Ⅳa 기궁경린암환자료효현저,안전성고,치득림상추엄응용。
Objectives:To investigate the efficacy and safety of two platinum -containing chemotherapy regimens to patients with Ⅰb2 ~Ⅳa squamous carcinoma of the cervix.Methods:80 patients with Ⅰb2 ~Ⅳa squamous carcinoma of the cervix in our hospital from February 201 0 to April 201 3were studied.With patients’in-formed consent,all the patients were divided into observation group and control group according to a random number table method.The control group was treated with concurrent radiotherapy and cisplatin and the observation group re-ceived fluorouracil and cisplatin combined with concurrent radiotherapy treatment.After treatment,the short -term efficacy and adverse reactions of the two groups were compared,and long -term outcome was followed up.Results:After 3 months,the total effective rate of the observation group and control group was 85.00% and 77.50% respec-tively,with significant difference (P <0.05).After 3 years of follow -up,the 3 -year survival rate of the observa-tion group (87.50%)was significantly higher than the control group (67.50%),with statistically significant difference (χ2 =4.5878,P =0.0322);the local recurrence rate and distant metastasis rate of the observation group (20.00%;1 7.50%)were significantly lower than the control group (42.50%;37.50%),with significant difference (P <0.05).Conclusion:Fluorouracil and cisplatin concurrent radiotherapy has a significant effect in treating patients ofⅠ b2 ~Ⅳa cervical squamous cell carcinoma,which is safe and worthy of clinical application.