中国当代医药
中國噹代醫藥
중국당대의약
PERSON
2015年
23期
15-18
,共4页
慢性乙型肝炎%抗病毒治疗%调节性T细胞
慢性乙型肝炎%抗病毒治療%調節性T細胞
만성을형간염%항병독치료%조절성T세포
Chronic hepatitis B%Antiviral therapy%Regulatory T cell
慢性乙型肝炎患者抗病毒治疗在抑制病毒复制的同时也影响机体免疫功能。调节性T细胞为体内具有免疫调节功能的T细胞亚群，能抑制HBV感染者特异性T细胞反应。研究慢性乙型肝炎患者抗病毒治疗对调节性T细胞数量及功能的影响，可以为探索更理想的免疫学指标来评价抗病毒应答反应，治疗效果，预测治疗终点、停药后复发，疾病预后等打下基础，也可能为慢性乙型肝炎患者制订更优化的抗病毒治疗策略确定方向。
慢性乙型肝炎患者抗病毒治療在抑製病毒複製的同時也影響機體免疫功能。調節性T細胞為體內具有免疫調節功能的T細胞亞群，能抑製HBV感染者特異性T細胞反應。研究慢性乙型肝炎患者抗病毒治療對調節性T細胞數量及功能的影響，可以為探索更理想的免疫學指標來評價抗病毒應答反應，治療效果，預測治療終點、停藥後複髮，疾病預後等打下基礎，也可能為慢性乙型肝炎患者製訂更優化的抗病毒治療策略確定方嚮。
만성을형간염환자항병독치료재억제병독복제적동시야영향궤체면역공능。조절성T세포위체내구유면역조절공능적T세포아군，능억제HBV감염자특이성T세포반응。연구만성을형간염환자항병독치료대조절성T세포수량급공능적영향，가이위탐색경이상적면역학지표래평개항병독응답반응，치료효과，예측치료종점、정약후복발，질병예후등타하기출，야가능위만성을형간염환자제정경우화적항병독치료책략학정방향。
Antiviral therapy inhibits viral replication and also has some influence on body’s immunity in patients with chronic hepatitis B.Regulatory T cell,a subset of T cells,has an immunomodulatory function in v iv o and can inhibit spe-cific T cell response in HBV infection patients.Study of antiviral therapy influencing on amount of regulatory T cell and its function in patients with chronic hepatitis B can lay foundations for probing into more ideal immunological indica-tors to assess the anti-viral responses,therapeutic efficacy,predict the termination of treatment and recurrence after ceasing medication,disease prognosis,and may also point out the direction for developing more optimal strategies of an-tiviral treatment in patients with chronic hepatitis B.
