中国医药导报
中國醫藥導報
중국의약도보
CHINA MEDICAL HERALD
2015年
24期
86-89
,共4页
糖耐量减低%2型糖尿病%肥胖%干预治疗
糖耐量減低%2型糖尿病%肥胖%榦預治療
당내량감저%2형당뇨병%비반%간예치료
Impaired glucose tolerance%Type 2 diabetes%Obesity%Intervention therapy
目的：调查随访经济发达农村城市化地区糖耐量减低(IGT)人群的自然转归及影响因素。方法对深圳市沙井街道2000年流行病学调查126例确诊IGT人群进行15年后转归追踪调查,采用统一调查表格询问病史,测量身高、体重、腰围及血压,计算体重指数(BMI),进行标准的75 g口服葡萄糖耐量试验,测定空腹血糖(FPG)及餐后2 h血糖(2hPG)。糖尿病(DM)及IGT诊断按1999年WHO诊断标准,肥胖按中国成人超重和肥胖症预防控制指南诊断标准。危险因素分析采用Logistic逐步回归分析。结果126例IGT患者中转化为DM 65例,转化率为51.6%,年转化率为3.44%；与转化为正常糖耐量患者(NGT组)比较,转为DM患者(DM组)的年龄、BMI、FBG、2hPG均明显升高,差异有统计学意义(P<0.05)。 Logistic逐步回归分析结果显示,与IGT转归为DM相关的危险因素是年龄(OR=1.166,95%CI 1.054~1.311,P=0.031)、BMI(OR=1.445,95%CI 1.152~2.802,P=0.0210)和2hPG (OR=3.015,95%CI 1.166~7.789,P=0.0214)。结论 IGT患者发生DM的主要影响因素为年龄、肥胖和2hPG；转化率低与当地IGT及肥胖患病率低相关；生活方式干预为最有效的预防手段,应加强糖尿病宣传教育,保持良好的饮食烹调方式,加强运动,控制超重及肥胖,继而减少DM的发生,这对经济发达农村城市化地区的DM防控有一定的指导意义。
目的：調查隨訪經濟髮達農村城市化地區糖耐量減低(IGT)人群的自然轉歸及影響因素。方法對深圳市沙井街道2000年流行病學調查126例確診IGT人群進行15年後轉歸追蹤調查,採用統一調查錶格詢問病史,測量身高、體重、腰圍及血壓,計算體重指數(BMI),進行標準的75 g口服葡萄糖耐量試驗,測定空腹血糖(FPG)及餐後2 h血糖(2hPG)。糖尿病(DM)及IGT診斷按1999年WHO診斷標準,肥胖按中國成人超重和肥胖癥預防控製指南診斷標準。危險因素分析採用Logistic逐步迴歸分析。結果126例IGT患者中轉化為DM 65例,轉化率為51.6%,年轉化率為3.44%；與轉化為正常糖耐量患者(NGT組)比較,轉為DM患者(DM組)的年齡、BMI、FBG、2hPG均明顯升高,差異有統計學意義(P<0.05)。 Logistic逐步迴歸分析結果顯示,與IGT轉歸為DM相關的危險因素是年齡(OR=1.166,95%CI 1.054~1.311,P=0.031)、BMI(OR=1.445,95%CI 1.152~2.802,P=0.0210)和2hPG (OR=3.015,95%CI 1.166~7.789,P=0.0214)。結論 IGT患者髮生DM的主要影響因素為年齡、肥胖和2hPG；轉化率低與噹地IGT及肥胖患病率低相關；生活方式榦預為最有效的預防手段,應加彊糖尿病宣傳教育,保持良好的飲食烹調方式,加彊運動,控製超重及肥胖,繼而減少DM的髮生,這對經濟髮達農村城市化地區的DM防控有一定的指導意義。
목적：조사수방경제발체농촌성시화지구당내량감저(IGT)인군적자연전귀급영향인소。방법대심수시사정가도2000년류행병학조사126례학진IGT인군진행15년후전귀추종조사,채용통일조사표격순문병사,측량신고、체중、요위급혈압,계산체중지수(BMI),진행표준적75 g구복포도당내량시험,측정공복혈당(FPG)급찬후2 h혈당(2hPG)。당뇨병(DM)급IGT진단안1999년WHO진단표준,비반안중국성인초중화비반증예방공제지남진단표준。위험인소분석채용Logistic축보회귀분석。결과126례IGT환자중전화위DM 65례,전화솔위51.6%,년전화솔위3.44%；여전화위정상당내량환자(NGT조)비교,전위DM환자(DM조)적년령、BMI、FBG、2hPG균명현승고,차이유통계학의의(P<0.05)。 Logistic축보회귀분석결과현시,여IGT전귀위DM상관적위험인소시년령(OR=1.166,95%CI 1.054~1.311,P=0.031)、BMI(OR=1.445,95%CI 1.152~2.802,P=0.0210)화2hPG (OR=3.015,95%CI 1.166~7.789,P=0.0214)。결론 IGT환자발생DM적주요영향인소위년령、비반화2hPG；전화솔저여당지IGT급비반환병솔저상관；생활방식간예위최유효적예방수단,응가강당뇨병선전교육,보지량호적음식팽조방식,가강운동,공제초중급비반,계이감소DM적발생,저대경제발체농촌성시화지구적DM방공유일정적지도의의。
Objective To investigate the natural outcome and influencing factors of glucose tolerance reduction (IGT) in the developed rural urbanization area. Methods A 15 years outcome tracking survey on 126 cases of IGT population confirmed by epidemiological investigation in 2000 in Shajing Street of Shenzhen City was carried out. A unified survey form was adopted to investigate medical history, measurements of height, weight, waist circumference and blood pres-sure, calculated body mass index (BMI). Standard OGTT was used to measure FPG and 2hPG. Diabetes mellitus (DM) and glucose tolerance (IGT) were diagnosed according to the 1999 WHO diagnostic criteria. Obesity was diagnosed ac-cording to Chinese adult overweight and obesity prevention and control guidelines. Risk factors were analyzed by Logis-tic stepwise regression. Results 65 cases conerted to DM among 126 patients with IGT, the conversion rate was 51.6%, the annual conversion rate was 3.44%. Compared with the patients conerted to nomal glucose tolerance (NGT group), age, BMI, FBG, 2hPG were significantly higher in DM group, the differences were statistically significant (P<0.05). Lo-gistic stepwise regression analysis results showed that age (OR=1.166, 95%CI 1.054-1.311, P= 0.0031), BMI (OR=1.445, 95%CI 1.152-2.802, P=0.0210) and 2hPG (OR=3.015, 95%CI 1.166-7.709, P=0.0214) were the risk factors of IGT conerted to DM. Conclusion Main influencing factors of IGT conerted to DM are age, obesity and 2hPG. Low con-version rate is related to low incidence of IGT and obesity in local. Lifestyle intervention is the most effective means of prevention, should strengthen the publicity and education of DM, maintain good cooking mode, strong motion, control overweight and obesity, in order to reduce the incidence of DM, which has a certain guidance meaning for DM preven-tion in economically developed rural urbanization area.
