CAJ | 학술논문

肝转移发生是导致结直肠癌患者预后不良的最重要的原因。近年来，结直肠癌肝转移治疗的治疗效果获得了令人鼓舞的进展。 HGF/c-Met信号转导通路在人体内正常细胞向恶性细胞转化、细胞运动、侵袭转移、上皮间质转化和组织再生等过程中发挥重要的作用。目前，通过对HGF/c-Met信号通路系统在结直肠癌肝转移中的作用机制的深入研究，发现HGF/c-Met信号转导通路系统在结直肠癌肝转移发生发展过程中发挥着重要的作用，并为研发有效的HGF/c-Met抑制剂提供了新的依据，一系列HGF/c-Met信号通路抑制剂的相继出现，为结直肠癌肝转移患者的治疗提供了新的思路。
간전이발생시도치결직장암환자예후불량적최중요적원인。근년래，결직장암간전이치료적치료효과획득료령인고무적진전。 HGF/c-Met신호전도통로재인체내정상세포향악성세포전화、세포운동、침습전이、상피간질전화화조직재생등과정중발휘중요적작용。목전，통과대HGF/c-Met신호통로계통재결직장암간전이중적작용궤제적심입연구，발현HGF/c-Met신호전도통로계통재결직장암간전이발생발전과정중발휘착중요적작용，병위연발유효적HGF/c-Met억제제제공료신적의거，일계렬HGF/c-Met신호통로억제제적상계출현，위결직장암간전이환자적치료제공료신적사로。
Liver metastasis remains a significant problem in the prognosis of colorectal cancer. In recent years, the therapeutic effect has achieved remarkable results in liver metastasis of colorectal cancer. HGF/c-Met signaling path-way plays an important role in the process of the transformation of normal cells into malignant cells, cell movement, in-vasion and metastasis, epithelial mesenchymal transition and tissue regeneration. Recent research findings have con-firmed that HGF/c-Met signaling pathway plays an pivotal role in the development of liver metastasis of colorectal can-cer. The appearance of some novel HGF/c-Met inhibitors provides the new idea for treatment of liver metastasis of col-orectal cancer. Further research of the mechanism of HGF/c-Met signaling pathway in liver metastasis of colorectal cancer could provide a foundation to develop effective HGF/c-Met inhibitors. The author will systematic review the progress of HGF/c-Met signaling pathway in liver metastasis of colorectal cancer.