中国医学创新
中國醫學創新
중국의학창신
MEDICAL INNOVATION OF CHINA
2015年
23期
119-121
,共3页
高强聚焦刀%晚期原发性肝癌%肝功能%NRS评分%生活质量
高彊聚焦刀%晚期原髮性肝癌%肝功能%NRS評分%生活質量
고강취초도%만기원발성간암%간공능%NRS평분%생활질량
High-intensity focused ultrasound%Advanced primary liver cancer%Liver function%NRS score%Quality of life
目的：观察高强聚焦刀（HIFU）联合艾迪注射液对于晚期原发性肝癌的治疗效果。方法：对本院收治的32例不能手术同时不能TACE、且不能放化疗、不能进行靶向药物治疗的原发性肝癌患者采用高强超声聚焦刀联合艾迪注射液治疗，观察治疗后临床症状、肝功能、腹痛及生活质量改善情况。结果：治疗前，所有患者均无显效和有效，经治疗后，根据KPS评分来评估患者生活质量的改善情况可知，显效11例，有效16例，无效5例，治疗总有效率为84.4%，治疗前后总有效率比较差异有统计学意义（P<0.05）。所有患者治疗后的腹胀、黄疸、腹水、尿量减少、恶心呕吐、乏力、腹痛等症状均较治疗前明显改善（P<0.05）。所有患者治疗后的肝功能Child分级、腹痛NRS评分均较治疗前明显改善（P<0.05）。OS最短为0.8个月，最长为12.3个月，中位OS为3.2个月。结论：高强聚焦刀联合艾迪注射液治疗晚期肝癌安全有效，不良反应轻，值得临床推广应用。
目的：觀察高彊聚焦刀（HIFU）聯閤艾迪註射液對于晚期原髮性肝癌的治療效果。方法：對本院收治的32例不能手術同時不能TACE、且不能放化療、不能進行靶嚮藥物治療的原髮性肝癌患者採用高彊超聲聚焦刀聯閤艾迪註射液治療，觀察治療後臨床癥狀、肝功能、腹痛及生活質量改善情況。結果：治療前，所有患者均無顯效和有效，經治療後，根據KPS評分來評估患者生活質量的改善情況可知，顯效11例，有效16例，無效5例，治療總有效率為84.4%，治療前後總有效率比較差異有統計學意義（P<0.05）。所有患者治療後的腹脹、黃疸、腹水、尿量減少、噁心嘔吐、乏力、腹痛等癥狀均較治療前明顯改善（P<0.05）。所有患者治療後的肝功能Child分級、腹痛NRS評分均較治療前明顯改善（P<0.05）。OS最短為0.8箇月，最長為12.3箇月，中位OS為3.2箇月。結論：高彊聚焦刀聯閤艾迪註射液治療晚期肝癌安全有效，不良反應輕，值得臨床推廣應用。
목적：관찰고강취초도（HIFU）연합애적주사액대우만기원발성간암적치료효과。방법：대본원수치적32례불능수술동시불능TACE、차불능방화료、불능진행파향약물치료적원발성간암환자채용고강초성취초도연합애적주사액치료，관찰치료후림상증상、간공능、복통급생활질량개선정황。결과：치료전，소유환자균무현효화유효，경치료후，근거KPS평분래평고환자생활질량적개선정황가지，현효11례，유효16례，무효5례，치료총유효솔위84.4%，치료전후총유효솔비교차이유통계학의의（P<0.05）。소유환자치료후적복창、황달、복수、뇨량감소、악심구토、핍력、복통등증상균교치료전명현개선（P<0.05）。소유환자치료후적간공능Child분급、복통NRS평분균교치료전명현개선（P<0.05）。OS최단위0.8개월，최장위12.3개월，중위OS위3.2개월。결론：고강취초도연합애적주사액치료만기간암안전유효，불량반응경，치득림상추엄응용。
Objective:To observe the clinical effect of high-intensity focused ultrasound(HIFU) combined with Eddy Injection for the treatment of advanced primary liver cancer.Method:32 patients with inoperable advanced primary liver cancer admitted to our hospital which could not be given transhepatic arterial chemotherapy and embolization,chemoradiation,and at the same time could not be targeted with conventional drug treatment were treated by high-intensity focused ultrasound combined with Eddy Injection,and the clinical symptoms,liver function,abdominal pain and improvement the quality of life after treatment of all patients were observed.Result:Before treatment,all patients had no obvious effect and effect.According to KPS score to assess the quality of life of patients with improved conditions,markedly effective in 11 cases,effective in 16 cases, invalid in 5 cases,the total effective rate was 84.4%,the difference was statistically significant in the total effective rate before and after treatment(P<0.05).The symptoms of abdominal distension,jaundice,ascites,urine volume reduction,nausea and vomiting,fatigue,abdominal pain of all patients after treatment were significantly improved compared with before treatment (P<0.05).The Child grade of liver function and NRS score of abdominal pain of all patients after treatment were significantly improved compared with before treatment(P<0.05).The shortest OS was 0.8 months,the longest was 12.3 months,the median OS was 3.2 months.Conclusion:High-intensity focused ultrasound combined with Eddy Injection in the treatment of advanced primary liver cancer is safe and effective,with light adverse reaction,it is worthy of clinical popularization and application.
