中国医学创新
中國醫學創新
중국의학창신
MEDICAL INNOVATION OF CHINA
2015年
23期
148-150,151
,共4页
PLCE1%单核苷酸多态性%肿瘤
PLCE1%單覈苷痠多態性%腫瘤
PLCE1%단핵감산다태성%종류
PLCE1%Single nucleotide polymorphism%Tumor
磷脂酶Cε1（PLCE1）是新近发现的磷脂酶C同工酶，其分子结构中特有的CDC25和RA结构域使其功能上与Ras家族小G蛋白关系密切。PLCE1激活后介导信号传导，从而调控某些基因的表达，调节细胞的生长、分化等过程。PLCE1基因单核苷酸多态性rs2274223（A>G）位点是目前研究最多的多态位点之一，最近发现，PLCE1及其基因多态性和肿瘤、肾病综合征、心脏疾病等多种疾病的发生相关。
燐脂酶Cε1（PLCE1）是新近髮現的燐脂酶C同工酶，其分子結構中特有的CDC25和RA結構域使其功能上與Ras傢族小G蛋白關繫密切。PLCE1激活後介導信號傳導，從而調控某些基因的錶達，調節細胞的生長、分化等過程。PLCE1基因單覈苷痠多態性rs2274223（A>G）位點是目前研究最多的多態位點之一，最近髮現，PLCE1及其基因多態性和腫瘤、腎病綜閤徵、心髒疾病等多種疾病的髮生相關。
린지매Cε1（PLCE1）시신근발현적린지매C동공매，기분자결구중특유적CDC25화RA결구역사기공능상여Ras가족소G단백관계밀절。PLCE1격활후개도신호전도，종이조공모사기인적표체，조절세포적생장、분화등과정。PLCE1기인단핵감산다태성rs2274223（A>G）위점시목전연구최다적다태위점지일，최근발현，PLCE1급기기인다태성화종류、신병종합정、심장질병등다충질병적발생상관。
Phospholipase C epsilon 1 gene(PLCE1) is a newly discovered C isoenzyme of phosphorus esterase,the structure of CDC25 and RA in its molecular structure is closely related to the small G protein of Ras family.PLCE1 mediates signal transduction after activation,regulate the expression of certain genes,regulate the growth and differentiation of cells.A single nucleotide polymorphism(rs2274223 A>G) in PLCE1 is currently one of the most studied of polymorphic loci.Recently discovered,PLCE1 and its gene polymorphism are associated with the occurrence of a variety of diseases such as tumor, nephrotic syndrome,heart disease and other diseases.
