CAJ | 학술논문

CALR基因突变是新发现的经典骨髓增殖性肿瘤(MPN)的生物学标志,其在原发性血小板增多症和原发性骨髓纤维化患者中的发生率为20％～ 35％,与特定临床特征和良好预后相关.文章对CALR基因突变在经典MPN中的生物学特征和临床意义进行介绍.
CALR기인돌변시신발현적경전골수증식성종류(MPN)적생물학표지,기재원발성혈소판증다증화원발성골수섬유화환자중적발생솔위20％～ 35％,여특정림상특정화량호예후상관.문장대CALR기인돌변재경전MPN중적생물학특정화림상의의진행개소.
CALR mutations are discovered in classic myeloproliferative neoplasms (MPN) as a new biomarker very recently.CALR mutations occur in about 20 ％-35 ％ essential thrombocythemia and primary myelofibrosis and are associated with some clinical features and favorable prognostic impact.This article reviews biological characteristics and clinical implications of CALR mutations in classic MPN.