CAJ | 학술논문

目的：探讨急性脑梗死患者血清炎性因子、组织型纤溶酶原激活物（t-PA）及快速抑制酶（PAI-1）的变化规律及其与预后的关系。方法选取急性脑梗死患者100例作为观察组，同期非急性脑梗死患者100例作为对照组，检测观察组患者在入院时、入院后不同时间的血清炎性因子、t-PA、PAI-1水平变化规律，并分析其与患者脑梗死面积、预后的关系。结果观察组患者入院时及入院后第3、7、14天的IL-6、IL-18、PAI-1及CRP水平均高于对照组（ P ＜0．05），而t-PA水平均低于对照组（ P ＜0．05）；观察组IL-6、IL-8、PAI及CRP水平在入院后呈逐步降低趋势与入院时比较差异有统计学意义（ P ＜0．05），而t-PA水平入院后第3、7天较入院时降低（ P ＜0．05），在入院后第14天较入院时升高（ P ＜0．05）。血清IL-6、IL-8、PAI-1及CRP水平比较：大梗死亚组＞中梗死亚组＞小梗死亚组（ P ＜0．05）；中梗死亚组预后不良亚组＞预后良好亚组；血清t-PA水平比较：大梗死亚组＜梗死亚组（ P ＜0．05），预后不良亚组＜预后良好亚组（ P ＜0．05）。结论急性脑梗死患者的IL-6、IL-18、PAI-1、t-PA及CRP水平较非脑梗死患者有显著差异，同时与患者的预后、梗死面积具有一定的关系。
목적：탐토급성뇌경사환자혈청염성인자、조직형섬용매원격활물（t-PA）급쾌속억제매（PAI-1）적변화규률급기여예후적관계。방법선취급성뇌경사환자100례작위관찰조，동기비급성뇌경사환자100례작위대조조，검측관찰조환자재입원시、입원후불동시간적혈청염성인자、t-PA、PAI-1수평변화규률，병분석기여환자뇌경사면적、예후적관계。결과관찰조환자입원시급입원후제3、7、14천적IL-6、IL-18、PAI-1급CRP수평균고우대조조（ P ＜0．05），이t-PA수평균저우대조조（ P ＜0．05）；관찰조IL-6、IL-8、PAI급CRP수평재입원후정축보강저추세여입원시비교차이유통계학의의（ P ＜0．05），이t-PA수평입원후제3、7천교입원시강저（ P ＜0．05），재입원후제14천교입원시승고（ P ＜0．05）。혈청IL-6、IL-8、PAI-1급CRP수평비교：대경사아조＞중경사아조＞소경사아조（ P ＜0．05）；중경사아조예후불량아조＞예후량호아조；혈청t-PA수평비교：대경사아조＜경사아조（ P ＜0．05），예후불량아조＜예후량호아조（ P ＜0．05）。결론급성뇌경사환자적IL-6、IL-18、PAI-1、t-PA급CRP수평교비뇌경사환자유현저차이，동시여환자적예후、경사면적구유일정적관계。
Objective To investigate the acute cerebral infarction serum inflammatory factor , tissue type plasminogen activator( t-PA) and rapid inhibition of the variation of the enzyme ( PAI1-) and relationship with prognosis .Methods Se-lected 100 cases of patients with acute cerebral infarction as the observation group , 100 cases of patients without acute cerebral infarction as control group .Changes of serum inflammatory factor , t-PA , PAI-1 were observed at different time of admission , after admission, and analyze its relationship with and prognosis of patients with cerebral infarction .Results The observation group patients’ IL-6 and IL-18, PAI-1 and CRP levels when admitted to hospital and 3, 7, 14 days after admission were higher than that of the control group ( P <0.05), and t-PA levels were lower than the control group ( P <0.05); observation group’s IL-6 and IL1-8, PAI-1, CRP levels on admission showed a gradual decreasing trend and showed statistically signifi -cant difference with at beginning of admission ( P <0.05 ) , and t-PA level after 3 and 7 days of admission were decreased (P <0.05), after 14 days of admission, it increased than at the beginning of the admission ( P <0.05).And serum IL-6, IL-8, and PAI-1 and CRP levels’ comparison:large infarction subgroup >median infarction subgroup >small infarction sub-group ( P <0.05);adverse prognosis subgroup >good prognosis subgroup;serum t-PA levels:large infarction subgroup <median infarction subgroup <small infarction subgroup ( P <0.05), adverse prognosis subgroup <good prognosis subgroup ( P <0.05).Concluison There were significant differences of IL-6, IL-18, PAI-1,and t-PA and CRP levels in patients with acute cerebral infarction and patients without cerebral infarction , acute cerebral infarction has certain relationship with prognosis of patients and infarct area.