CAJ | 학술논문

研究了一种新型的硫醚在紫外光照条件下与二苯甲酮及其衍生物的加成反应,实现了高效α-碳氢键官能团化的方法。考察了紫外光波长、反应温度、反应物的浓度、不同 Lewis 酸催化剂等因素对产物分离收率的影响,得出的最佳反应条件为：紫外光波长为313 nm、反应温度为室温、反应物4,4'-二甲氧基二苯甲酮的物质的量为0.02 mmol、Lewis 酸催化剂为 AlCl3。在最佳反应条件下,目标产物双(4-甲氧基苯基)(2-四氢噻吩基)甲醇的分离产率为57%,并探讨了反应的机理。
연구료일충신형적류미재자외광조조건하여이분갑동급기연생물적가성반응,실현료고효α-탄경건관능단화적방법。고찰료자외광파장、반응온도、반응물적농도、불동 Lewis 산최화제등인소대산물분리수솔적영향,득출적최가반응조건위：자외광파장위313 nm、반응온도위실온、반응물4,4'-이갑양기이분갑동적물질적량위0.02 mmol、Lewis 산최화제위 AlCl3。재최가반응조건하,목표산물쌍(4-갑양기분기)(2-사경새분기)갑순적분리산솔위57%,병탐토료반응적궤리。
A new protocol for the photo-induced addition reaction of sulfides with benzophenones has been extablished, affording the α-functionalized products.The effects of UV wavelength,temperature,concentration of reactants,concentration of Lewis acid catalyst and other factors on the isolated product yield have been investigated.The optimum condition is:UV light wavelength of 313 nm,room temperature,0.02 mmol of 4,4-dimethoxybenzophenone,0.002 mmol of the catalyst of AlCl3.Under optimum conditions, the isolated yield of the desired product (4-methoxyphenyl ) (2-tetrahydro-thienyl ) methanol is 57%.Based on the experiment results and corresponding literature reports in this field,a possible mechanism is discussed.