CAJ | 학술논문

目的：观察瑞舒伐他汀钙辅治短暂性脑缺血发作（TIA）患者对颈动脉斑块和血脂的影响。方法选取TIA患者76例为研究对象，按随机数字表法分为治疗组39例和对照组37例。对照组给予尼莫地平、阿司匹林、胞二磷胆碱、低分子右旋糖酐等常规药物治疗，治疗组在对照组治疗基础上给予瑞舒伐他汀钙10 mg／d，连续服用6个月。治疗前后分别行颈动脉粥样硬化斑块、血脂检测；随访6个月，分别记录脑血管疾病发生情况及不良反应。结果治疗后治疗组颈动脉内膜中层厚度（ IMT）明显变薄，斑块面积显著缩小，TC、TG、LDL-C水平较治疗前明显下降（P﹤0．05），HDL-C无统计学意义（ P ＜0．05）；对照组治疗前后上述指标均无显著变化，差异无统计学意义（ P ＞0．05）；2组治疗后，颈动脉内膜和斑块面积、TC、TG、LDL-C水平比较差异均有统计学意义（ P ＜0．05）。治疗组脑血管疾病发生率（10．3％）明显低于对照组（21．6％）（χ2＝4．762， P ＜0．05），2组患者治疗期间均未发生严重不良反应。结论瑞舒伐他汀钙辅治能有效减轻颈动脉粥样硬化斑块，降低血脂水平和脑血管疾病事件的发生率，值得临床应用推广。
목적：관찰서서벌타정개보치단잠성뇌결혈발작（TIA）환자대경동맥반괴화혈지적영향。방법선취TIA환자76례위연구대상，안수궤수자표법분위치료조39례화대조조37례。대조조급여니막지평、아사필림、포이린담감、저분자우선당항등상규약물치료，치료조재대조조치료기출상급여서서벌타정개10 mg／d，련속복용6개월。치료전후분별행경동맥죽양경화반괴、혈지검측；수방6개월，분별기록뇌혈관질병발생정황급불량반응。결과치료후치료조경동맥내막중층후도（ IMT）명현변박，반괴면적현저축소，TC、TG、LDL-C수평교치료전명현하강（P﹤0．05），HDL-C무통계학의의（ P ＜0．05）；대조조치료전후상술지표균무현저변화，차이무통계학의의（ P ＞0．05）；2조치료후，경동맥내막화반괴면적、TC、TG、LDL-C수평비교차이균유통계학의의（ P ＜0．05）。치료조뇌혈관질병발생솔（10．3％）명현저우대조조（21．6％）（χ2＝4．762， P ＜0．05），2조환자치료기간균미발생엄중불량반응。결론서서벌타정개보치능유효감경경동맥죽양경화반괴，강저혈지수평화뇌혈관질병사건적발생솔，치득림상응용추엄。
Objective To observe the effect of atorvastatin calcium on carotid plaque and blood lipid in patients with transient ischemic attack ( TIA) .Methods Selected 76 TIA patients as the research object , according to the random number table, they were divided into treatment group with 39 cases and control group with 37 cases.The control group was given ni-modipine and aspirin , cell diphosphate choline , low molecular weight dextran and conventional drug therapy , based on the above treatment, the treatment group also given rosuvastatin calcium 10 mg/d, for taking six months.Carotid atherosclerosis plaque and blood lipid were detected before and after treatment .The incidence and adverse reactions of cerebrovascular disea-ses were recorded after 6 months of follow-up.Results After treatment, treatment group’s carotid artery intima-media thick-ness ( IMT) became thin, plaque area was significantly reduced , TC, TG, LDL-C levels decreased obviously than before treatment ( t =3.062, t =3.641, t =3.016, t =4.019, t =2.943, P <0.05), HDL-C have no statistically significant (t =1.951, P <0.05), and in the control group before and after treatment , the index had no significant change , the differ-ence was not statistically significant ( t =0.401, t =1.009, t =0.941, t =1.038, t =1.131, t =0.491, P >0.05).In the treatment group , the carotid artery intima and plaque area , TC, TG, LDL-C level differences were statistically significant ( P <0.05).In treatment group, cerebral blood vessel disease incidence rate (10.3%) was significantly lower than that of the control group (21.6%) (χ2 =4.762, P <0.05).During the treatment, the patients in both of the two groups did not oc-cur serious adverse reactions .Conclusion Rosuvastatin calcium assisted treatment can effectively reduce the carotid athero-sclerosis plaque , reduce the incidence of blood lipid level and cerebrovascular events , it is worthy of clinical application .