CAJ | 학술논문

目的：探讨连花清瘟胶囊治疗慢性阻塞性肺疾病患者临床效果及其对肺功能、血气指标及炎性因子[肿瘤坏死因子-α（TNF-α）、白细胞介素-8（IL-8）和白细胞素素-17（IL-17）]水平的影响。方法选择2014年1月—2015年2月内科住院或门诊治疗的慢性阻塞性肺疾病患者72例，按随机数字表法分为2组，每组36例。对照组给予常规治疗，观察组在对照组基础上加服连花清瘟胶囊；治疗10 d后观察2组患者临床疗效、肺功能、血气指标及TNF-α、IL-8和IL-17水平变化。结果观察组总有效率显著高于对照组（94．4％vs 72．2％，χ2＝17．71， P ＜0．05）。治疗后2组患者肺功能指标、第1秒用力呼气容积（ FEV1）、第1秒用力呼气容积专用力肺活量比值（ FEV1／FVC）、血气指标[动脉血氧分压（ PaO2）、二氧化碳分压（ PaCO2）]、TNF-α、IL-8和IL-17水平较治疗前显著改善，差异具有统计学意义（ P ＜0．05）；且观察组改善程度优于对照组，差异具有统计学意义（ P ＜0．05）。2组治疗前后pH值均无明显变化（P ＞0．05），治疗期间2组患者血压、心率、肝肾功能及血、尿常规均未发生明显改变，无其他不良反应。结论连花清瘟胶囊能显著改善慢性阻塞性肺疾病患者的临床疗效，能有效抑制炎性因子释放，从而减轻气道炎性反应作用。
목적：탐토련화청온효낭치료만성조새성폐질병환자림상효과급기대폐공능、혈기지표급염성인자[종류배사인자-α（TNF-α）、백세포개소-8（IL-8）화백세포소소-17（IL-17）]수평적영향。방법선택2014년1월—2015년2월내과주원혹문진치료적만성조새성폐질병환자72례，안수궤수자표법분위2조，매조36례。대조조급여상규치료，관찰조재대조조기출상가복련화청온효낭；치료10 d후관찰2조환자림상료효、폐공능、혈기지표급TNF-α、IL-8화IL-17수평변화。결과관찰조총유효솔현저고우대조조（94．4％vs 72．2％，χ2＝17．71， P ＜0．05）。치료후2조환자폐공능지표、제1초용력호기용적（ FEV1）、제1초용력호기용적전용력폐활량비치（ FEV1／FVC）、혈기지표[동맥혈양분압（ PaO2）、이양화탄분압（ PaCO2）]、TNF-α、IL-8화IL-17수평교치료전현저개선，차이구유통계학의의（ P ＜0．05）；차관찰조개선정도우우대조조，차이구유통계학의의（ P ＜0．05）。2조치료전후pH치균무명현변화（P ＞0．05），치료기간2조환자혈압、심솔、간신공능급혈、뇨상규균미발생명현개변，무기타불량반응。결론련화청온효낭능현저개선만성조새성폐질병환자적림상료효，능유효억제염성인자석방，종이감경기도염성반응작용。
Objective To investigate the effect of the Lianhuaqingwen capsules on the pulmonary function , blood gas index and inflammatory factor tumor necrosis factor alpha (TNF-alpha),interleukin 8 (IL-8) and IL-17 in patients with chron-ic obstructive pulmonary disease (COPD).Methods From January 2014 to February 2015, 72 cases inpatient or outpatients who received treatment for chronic obstructive pulmonary disease were enrolled .They were randomly divided into 2 groups ac-cording to the random number table , 36 cases in each group .The control group was given conventional treatment , the observa-tion group on the basis of treatment in the control group , also added Lianhuaqingwen capsules;treatment lasted for 10 days. Then observed the clinical curative effect of 2 groups of patients, lung function and blood gas index and level of TNF-α,IL-8 and IL-17 level changes were compared .Results The total efficiency of observation group was significantly higher than that of the control group (94.4%vs.72.2%,χ2 =17.71, P <0.05);after treatment, the 2 groups’ patients’ pulmonary func-tion index, forced expiratory volume in one second ( FEV1 ) , FEV1/FVC ratio ( FEV1/FVC) , blood gas indexes ( PaO2 ) , partial pressure of carbon dioxide ( PaCO2 ) , TNF-α,IL-8 and IL-17 levels were significantly improved compared with before treatment, the difference was statistically significant ( P <0.05) between the 2 groups, the observation group’s improvement was better than the control group , the difference was statistically significant ( P <0.05); the 2 groups’ pH value did not change significantly before and after treatment ( P >0.05), during treatment, 2 groups’ patients’ heart rate, blood pressure and blood urine routine , liver and kidney function were not changed significantly , no other adverse reactions were found .Con-clusion Lianhuaqingwen capsules can significantly improve the clinical efficacy of patients with chronic obstructive pulmo -nary disease ( COPD) , it can effectively inhibit the release of inflammatory cytokines , thereby reducing airway inflammatory reaction.