CAJ | 학술논문

目的：通过 Meta 分析探讨代谢综合征与结肠癌的关系。方法计算机检索中国知网、万方数据库、PubMed、Ovid-sp 数据库,时限为1990年1月至2014年5月。按纳入和排除标准,进行文献筛选及资料提取。采用 STATA12.0软件进行 Meta分析。结果共纳入8篇文献(6项队列研究、2项病例对照研究)。Meta 分析结果显示,代谢综合征结肠癌发病风险明显高于对照组(OR=1.43,95%CI ：1.23~1.66,P <0.05)；分层分析发现,男性人群中,代谢综合征结肠癌发病风险高于对照组(OR =1.50,95%CI ：1.22~1.84,P <0.05),然而,女性人群中,其合并效应量 OR 为1.39(95%CI ：0.98~1.96,P =0.07),差异却无统计学意义。另外,与对照组相比,代谢综合征结肠癌死亡风险并未发生变化(OR=1.22,95%CI ：0.92~1.63,P =0.17)。结论代谢综合征与结肠癌发病有一定联系,但存在性别差异。代谢综合征结肠癌死亡风险并未增加,有待更多前瞻性队列研究进一步证实。
목적：통과 Meta 분석탐토대사종합정여결장암적관계。방법계산궤검색중국지망、만방수거고、PubMed、Ovid-sp 수거고,시한위1990년1월지2014년5월。안납입화배제표준,진행문헌사선급자료제취。채용 STATA12.0연건진행 Meta분석。결과공납입8편문헌(6항대렬연구、2항병례대조연구)。Meta 분석결과현시,대사종합정결장암발병풍험명현고우대조조(OR=1.43,95%CI ：1.23~1.66,P <0.05)；분층분석발현,남성인군중,대사종합정결장암발병풍험고우대조조(OR =1.50,95%CI ：1.22~1.84,P <0.05),연이,녀성인군중,기합병효응량 OR 위1.39(95%CI ：0.98~1.96,P =0.07),차이각무통계학의의。령외,여대조조상비,대사종합정결장암사망풍험병미발생변화(OR=1.22,95%CI ：0.92~1.63,P =0.17)。결론대사종합정여결장암발병유일정련계,단존재성별차이。대사종합정결장암사망풍험병미증가,유대경다전첨성대렬연구진일보증실。
Objective To investigate the association between Metabolic syndrome and colon cancer.Methods A literature search was performed through PubMed,Ovidsp,CNKI and Wangfang Data within the time limit of January 1 990 to May 2014.Ac-cording to the inclusion and exclusion criteria,the studies were screened and the data were extracted.Then Meta-analysis was per-formed using Stata Statistical Software version 12.0.Results A total of 8 studies(6 cohort studies and 2 case-control studies)met the inclusion criteria.Meta analysis showed that patients with Metabolic syndrome had a higher risk of colon cancer incidence com-pared with the control group without Metabolic syndrome(OR =1.43,95%CI :1.23 - 1.66,P <0.05 ).Stratified analysis showed Metabolic syndrome had a higher risk of colon cancer incidence in male(OR=1.50,95%CI :1.22-1.84,P <0.05),but in female, this association was not found(OR=1.39,95%CI :0.98- 1.96,P =0.07).In addition,Meta analysis showed that Metabolic syn-drome was not associated with an increased risk of colon cancer mortality(OR=1.22,95%CI :0.92-1.63,P =0.1 7).Conclusion This Meta analysis indicated a positive association between Metabolic syndrome and colon cancer incidence in male,but not in fe-male.Metabolic syndrome might not be associated with an increased risk of colon cancer mortality,yet it needs more prospective co-hort studies to confirm the conclusion.