CAJ | 학술논문

目的：研究汉防己甲素(Tet)对晚期非小细胞肺癌的放射增敏作用及不良反应。方法经病理学或细胞学确诊的82例晚期非小细胞肺癌患者,首程治疗均给以放疗,分为3组：Tet 组、紫杉醇组及单纯放疗组。Tet 组30例从放疗第1天开始服用 Tet,每天3次,每次40 mg,直至放疗结束。紫杉醇组29例在放疗期间每周静脉滴注紫杉醇1次,每次60 mg。单纯放疗组23例仅行放疗。结果Tet 与紫杉醇有相同的放疗增敏作用,两者总有效率均高于单纯放疗组,差异有统计学意义(P <0.05)。放射性肺炎总发生率 Tet 组明显低于其余两组(P <0.05)。Tet 组一年内无病生存率高于其他两组。结论Tet 有紫杉醇相当的放疗增敏作用,并能减轻放疗不良反应。
목적：연구한방기갑소(Tet)대만기비소세포폐암적방사증민작용급불량반응。방법경병이학혹세포학학진적82례만기비소세포폐암환자,수정치료균급이방료,분위3조：Tet 조、자삼순조급단순방료조。Tet 조30례종방료제1천개시복용 Tet,매천3차,매차40 mg,직지방료결속。자삼순조29례재방료기간매주정맥적주자삼순1차,매차60 mg。단순방료조23례부행방료。결과Tet 여자삼순유상동적방료증민작용,량자총유효솔균고우단순방료조,차이유통계학의의(P <0.05)。방사성폐염총발생솔 Tet 조명현저우기여량조(P <0.05)。Tet 조일년내무병생존솔고우기타량조。결론Tet 유자삼순상당적방료증민작용,병능감경방료불량반응。
Objective To study the radiosensitization effects of tetrandrine on advanced non small cell lung cancer and its toxicity.Methods The patients of 82 cases with advanced non-small cell lung cancer were confirmed by pathology or cytology.The first course of treatment was treated with radiation therapy.Patients were divided into three groups:tetrandrine group,paclitaxel group and radiotherapy group.Tetrandrine group(30 cases)took radiotherapy with 40 mg tetrandrine(3 times a day)from the first day to the ending.Paclitaxel group (29 cases)took radiotherapy with intravenous infusion of 60 mg paclitaxel(once a week).Radio-therapy group (23 cases)only received radiotherapy.Results Tetrandrine and paclitaxel had the same radiosensitizing effect in ra-diotherapy.The total effective rate of tetrandrine and paclitaxel group was higher than radiotherapy group (P <0.05 ).The inci-dence of radiation pneumonitis in tetrandrine group was significantly lower than the other two groups (P <0.05).The one year free disease survival rate was promoted in tetrandrine group than other groups.Conclusion Tetrandrine was known as the same radia-tion sensitizing effect of paclitaxel fairly,which can reduce the toxicity of radiotherapy.