重庆医学
重慶醫學
중경의학
CHONGQING MEDICAL JOURNAL
2015年
24期
3350-3351,3354
,共3页
糖尿病,2 型%人体质量指数%非酒精性脂肪肝%nesfatin-1
糖尿病,2 型%人體質量指數%非酒精性脂肪肝%nesfatin-1
당뇨병,2 형%인체질량지수%비주정성지방간%nesfatin-1
diabetes mellitus,type 2%body mass index%nonalcoholic fatty live%nesfatin-1
目的：观察2型糖尿病(T2DM)伴或不伴非酒精性脂肪肝(NAFLD)患者血清 nesfatin-1水平的变化。方法检测T2DM 组(211例,其中 T2DM 不伴 NAFLD 组98例,T2DM 伴 NAFLD 组113例)和对照组(NGT)组(75例)的空腹血清 nesfa-tin-1水平,同时测定身高、体质量、血糖(GLU)、血脂谱、胰岛素水平(INS)、糖化血红蛋白(HbA1c)、谷丙转氨酶水平(ALT),计算BMI、胰岛素抵抗指数(HOMA-IR)。结果T2DM 组血清 nesfatin-1水平均明显高于 NGT 组(P <0.05),T2DM 组中 T2DM 伴NAFLD 亚组血清 nesfatin-1水平高于 T2DM 不伴 NAFLD 组(P <0.05)。T2DM 组 nesfatin-1与病程中度相关(r=-0.477,P <0.05)T2DM 组中脂肪肝的发生与 BMI、TG、nesfatin-1有关(P <0.05)。结论nesfatin-1可能参与 T2DM 及 NAFLD 的发生。
目的：觀察2型糖尿病(T2DM)伴或不伴非酒精性脂肪肝(NAFLD)患者血清 nesfatin-1水平的變化。方法檢測T2DM 組(211例,其中 T2DM 不伴 NAFLD 組98例,T2DM 伴 NAFLD 組113例)和對照組(NGT)組(75例)的空腹血清 nesfa-tin-1水平,同時測定身高、體質量、血糖(GLU)、血脂譜、胰島素水平(INS)、糖化血紅蛋白(HbA1c)、穀丙轉氨酶水平(ALT),計算BMI、胰島素牴抗指數(HOMA-IR)。結果T2DM 組血清 nesfatin-1水平均明顯高于 NGT 組(P <0.05),T2DM 組中 T2DM 伴NAFLD 亞組血清 nesfatin-1水平高于 T2DM 不伴 NAFLD 組(P <0.05)。T2DM 組 nesfatin-1與病程中度相關(r=-0.477,P <0.05)T2DM 組中脂肪肝的髮生與 BMI、TG、nesfatin-1有關(P <0.05)。結論nesfatin-1可能參與 T2DM 及 NAFLD 的髮生。
목적：관찰2형당뇨병(T2DM)반혹불반비주정성지방간(NAFLD)환자혈청 nesfatin-1수평적변화。방법검측T2DM 조(211례,기중 T2DM 불반 NAFLD 조98례,T2DM 반 NAFLD 조113례)화대조조(NGT)조(75례)적공복혈청 nesfa-tin-1수평,동시측정신고、체질량、혈당(GLU)、혈지보、이도소수평(INS)、당화혈홍단백(HbA1c)、곡병전안매수평(ALT),계산BMI、이도소저항지수(HOMA-IR)。결과T2DM 조혈청 nesfatin-1수평균명현고우 NGT 조(P <0.05),T2DM 조중 T2DM 반NAFLD 아조혈청 nesfatin-1수평고우 T2DM 불반 NAFLD 조(P <0.05)。T2DM 조 nesfatin-1여병정중도상관(r=-0.477,P <0.05)T2DM 조중지방간적발생여 BMI、TG、nesfatin-1유관(P <0.05)。결론nesfatin-1가능삼여 T2DM 급 NAFLD 적발생。
Objective To investigate serum nesfatin-1 levels in type 2 diabetes (T2DM)patients with or without nonalcohol-ic fatty liver(NAFLD).Methods The hight,weight,serum GLU,lipid profiles,INS,HbA1c,ALT,nesfatin-1 levels were measured in 21 1 T2DM patients[98 without NAFLD(TD2M without NAFLD group)and 1 13 with NAFLD(TD2M with NAFLD group)] and 75 normal subjects(NGT group).BMI、HOMA-IR were also calculated.Results The serum nesfatin-1 level was significantly higher in T2DM group than those in NGT group(P <0.05),and T2DM with NAFLD group had higher nesfatin-1 level than T2DM without NAFLD group (P < 0.05 ).There was a close relation between nefastin-1 of T2DM group and course of disease (r=-0.447,P <0.05).NAFLD existed a significant correlation with BMI、TG and nesfatin-1 (P <0.05).Conclusion nesfatin-1 may partially contribute to the pathogenesis of T2DM and NAFLD.
