CAJ | 학술논문

目的：比较EPO-β与EPO-α对肾性贫血的治疗效果及使用剂量。方法将139例维持性血液透析患者按所使用EPO不同分为EPO-β组(57例)和EPO-α组(82例),比较两组的血红蛋白、铁蛋白、转铁蛋白饱和度、甲状旁腺激素、EPO使用剂量及EPO指数等。结果两组患者的血红蛋白分布基本一致( P>0．05),两EPO-β、EPO-α组患者的铁蛋白(567 ng/mL vs．461 ng/mL)、转铁蛋白饱和度(28．0% vs．27．5%)、甲状旁腺激素(713 pg/mL vs．546 pg/mL)水平比较差异无统计学意义(P>0．05)。与EPO-α组比较,EPO-β组的EPO周使用剂量(4894 U vs．10073 U)及EPO指数(15787 U/% vs．32493 U/%)更低(P<0．001)。结论在达到相同的血红蛋白水平的前提下,EPO-β的使用剂量明显小于EPO-α,可能减少大剂量使用EPO所带来的潜在风险。
목적：비교EPO-β여EPO-α대신성빈혈적치료효과급사용제량。방법장139례유지성혈액투석환자안소사용EPO불동분위EPO-β조(57례)화EPO-α조(82례),비교량조적혈홍단백、철단백、전철단백포화도、갑상방선격소、EPO사용제량급EPO지수등。결과량조환자적혈홍단백분포기본일치( P>0．05),량EPO-β、EPO-α조환자적철단백(567 ng/mL vs．461 ng/mL)、전철단백포화도(28．0% vs．27．5%)、갑상방선격소(713 pg/mL vs．546 pg/mL)수평비교차이무통계학의의(P>0．05)。여EPO-α조비교,EPO-β조적EPO주사용제량(4894 U vs．10073 U)급EPO지수(15787 U/% vs．32493 U/%)경저(P<0．001)。결론재체도상동적혈홍단백수평적전제하,EPO-β적사용제량명현소우EPO-α,가능감소대제량사용EPO소대래적잠재풍험。
Objective To compare the efficacy and dosage of EPO-βand EPO-αin the treatment of renal ane-mia. Methods 139 maintenance hemodialysis patients were divided into EPO-β group ( n =57 ) and EPO-α group (n=82),the haemoglobin,ferritin,transferrin saturation,parathyroid hormone,epoetin dosage and epoetin index were compared between the two groups. Results The distribution of haemoglobin of the two groups was essentially identi-cal,and there was no significant difference in the ferritin (567 ng/mL vs. 461 ng/mL),transferrin saturation (28. 0%vs. 27. 5%) and parathyroid hormone (713 pg/mL vs. 546 pg/mL) between EPO-β group and EPO-α group ( P >0. 05),but the weekly EPO-β dosage (4 894 U vs. 10 073 U) and epoetin index (15 787 U/% vs. 32 493 U/%) in EPO-β group were much lower than those of EPO-α group ( P<0. 05 ) . Conclusion EPO-β could achieve the same haemoglobin level as EPO-α with lower dosage and reduce the potential risk due to the high dosage of epoetin use.