CAJ | 학술논문

目的：对丙戊酸钠( VPA)治疗癫疒间病例的血药浓度进行监测并评价其疗效。方法采用高效液相色谱法对3183例次服用丙戊酸钠的癫疒间患儿进行血药浓度监测。结果1763例次(55．39%)丙戊酸钠血药浓度在有效治疗范围(50~100μg/mL )，<50μg/mL 者1262例次(39．65%)，>100μg/mL者158例次(4．96%)。结论丙戊酸钠的血药浓度个体化差异大，其抗癫疒间的疗效、不良反应与血药浓度密切相关，应进行血药浓度监测。
목적：대병무산납( VPA)치료전녁간병례적혈약농도진행감측병평개기료효。방법채용고효액상색보법대3183례차복용병무산납적전녁간환인진행혈약농도감측。결과1763례차(55．39%)병무산납혈약농도재유효치료범위(50~100μg/mL )，<50μg/mL 자1262례차(39．65%)，>100μg/mL자158례차(4．96%)。결론병무산납적혈약농도개체화차이대，기항전녁간적료효、불량반응여혈약농도밀절상관，응진행혈약농도감측。
Objective To monitor the drug concentration of sodium valproate in the treatment of epilepsy,and evaluate the therapeutic effect. Methods The blood drug concentration of 3 183 epilepsy children administrated with sodium valproate was determined by HPLC. Results The serum concentration of 1 763 cases (55. 39%) were within the effective serum concentration (50 ~100 μg/mL),the concentration of 1 262 cases (39. 65%) was less than 50μg/mL,and the concentration of 158 cases (4. 96%) was higher than 100 μg/mL. Conclusion The serum concentra-tion of sodium valproate varied greatly in epileptic patients,and the therapeutic effect and adverse reaction were closely related to the plasma concentration,therefore,the blood drug concentration should be monitored routinely.