CAJ | 학술논문

目的：观察神经节苷脂对脑出血患者血清髓鞘碱性蛋白及凝血酶的影响。方法将我院128例脑出血患者随机分为2组，对照组患者(64例)进行常规药物治疗，观察组患者(64例)在常规药物治疗的基础上加用神经节苷脂治疗。测定两组患者治疗前后血清髓鞘碱性蛋白及凝血酶变化情况，统计两组患者治疗后血肿体积变化情况。在治疗前和治疗后1、3个月分别对患者进行ADL评分，并统计治疗后疗效情况。结果治疗前两组患者血清MBP、凝血酶水平、水肿体积、ADL评分比较差异无统计学意义( P>0．05)。治疗后，观察组患者的血清MBP及凝血酶水平均低于对照组( P<0．05)。治疗后，两组患者血肿体积均明显缩小，且观察组患者治疗后7、15 d水肿体积均明显小于对照组(P<0．05)。治疗后1、3个月，观察组患者ADL评分均明显高于对照组(P<0．05)。观察组治疗有效率为95．31%，明显高于对照组的71．88%(P<0．05)。结论神经节苷脂可有效降低脑出血患者血清髓鞘碱性蛋白及凝血酶的浓度，恢复患者日常生活能力，提高治疗效果。
목적：관찰신경절감지대뇌출혈환자혈청수초감성단백급응혈매적영향。방법장아원128례뇌출혈환자수궤분위2조，대조조환자(64례)진행상규약물치료，관찰조환자(64례)재상규약물치료적기출상가용신경절감지치료。측정량조환자치료전후혈청수초감성단백급응혈매변화정황，통계량조환자치료후혈종체적변화정황。재치료전화치료후1、3개월분별대환자진행ADL평분，병통계치료후료효정황。결과치료전량조환자혈청MBP、응혈매수평、수종체적、ADL평분비교차이무통계학의의( P>0．05)。치료후，관찰조환자적혈청MBP급응혈매수평균저우대조조( P<0．05)。치료후，량조환자혈종체적균명현축소，차관찰조환자치료후7、15 d수종체적균명현소우대조조(P<0．05)。치료후1、3개월，관찰조환자ADL평분균명현고우대조조(P<0．05)。관찰조치료유효솔위95．31%，명현고우대조조적71．88%(P<0．05)。결론신경절감지가유효강저뇌출혈환자혈청수초감성단백급응혈매적농도，회복환자일상생활능력，제고치료효과。
Objective To analyze the effect of ganglioside on serum myelin basic protein and thrombin in cer-ebral hemorrhage. Methods One hundred and twenty-eight cases of cerebral hemorrhage patients in our hospital were collected and randomly divided into two groups. Control group (n=64) was treated with conventional treatment,and observation group was treated with conventional treatment and ganglioside. The serum myelin basic protein,thrombin changes and hematoma volume change before and after treatment was recorded. The daily living scores ( ADL ) at 1 month and 3 months after treatment were counted. Results There was no significant difference in the serum MBP, thrombin levels, edema volume, ADL score of patients before treatment between the two groups ( P >0. 05 ) . After treatment,the MBP and thrombin serum levels in observation group were lower than those of control group ( P <0. 05);the hematoma volume of two groups decreased,and the volume in observation group was smaller than that of control group at 7 d and 15 d after treatment (P<0. 05);the ADL score in observation group was higher than that of control group at 1 and 3 months after treatment (P<0. 05). The effective rate of observation group was higher than that of control group (95. 31% vs. 71. 88%,P<0. 05). Conclusion Ganglioside could reduce the serum myelin basic pro-tein and thrombin in cerebral hemorrhage,and the patients′ daily life skills is recovered,the therapeutic effect is im-proved.