CAJ | 학술논문

目的：观察柴胡加龙骨牡蛎汤联合帕罗西汀治疗广泛性焦虑障碍的效果。方法采用随机数字表法将80例符合《精神障碍诊断与统计手册（第4版）》（DSM - IV）广泛性焦虑障碍诊断标准的患者分为研究组和对照组各40例，研究组予帕罗西汀联合中药柴胡加龙骨牡蛎汤加减，对照组使用帕罗西汀治疗，治疗6～12月（中位治疗时间8.2月）。于治疗前后进行汉密尔顿焦虑量表14项版（HAMA -14）和汉密尔顿抑郁量表17项版（HAMD-17）评定，HAMD -17评分＜17分者入组以排除明显抑郁状态或障碍。结果两组治疗后 HAMA -14评分均下降，差异有统计学意义（P ＜0.05）；研究组 HAMA -14评分下降更多，且总评分、精神焦虑评分、躯体焦虑评分下降值均大于对照组，差异有统计学意义（P ＜0.05）；研究组帕罗西汀用量小于对照组，差异有统计学意义（P ＜0.05）；两组合并用药情况：研究组合并用药更少，帕罗西汀使用量更小，不良反应更少，差异有统计学意义（P ＜0.05）。结论柴胡加龙骨牡蛎汤联合帕罗西汀对广泛性焦虑障碍的疗效和安全性较单用帕罗西汀好，不仅能减轻患者精神焦虑，对躯体性焦虑也有良好效果。
목적：관찰시호가용골모려탕연합파라서정치료엄범성초필장애적효과。방법채용수궤수자표법장80례부합《정신장애진단여통계수책（제4판）》（DSM - IV）엄범성초필장애진단표준적환자분위연구조화대조조각40례，연구조여파라서정연합중약시호가용골모려탕가감，대조조사용파라서정치료，치료6～12월（중위치료시간8.2월）。우치료전후진행한밀이돈초필량표14항판（HAMA -14）화한밀이돈억욱량표17항판（HAMD-17）평정，HAMD -17평분＜17분자입조이배제명현억욱상태혹장애。결과량조치료후 HAMA -14평분균하강，차이유통계학의의（P ＜0.05）；연구조 HAMA -14평분하강경다，차총평분、정신초필평분、구체초필평분하강치균대우대조조，차이유통계학의의（P ＜0.05）；연구조파라서정용량소우대조조，차이유통계학의의（P ＜0.05）；량조합병용약정황：연구조합병용약경소，파라서정사용량경소，불량반응경소，차이유통계학의의（P ＜0.05）。결론시호가용골모려탕연합파라서정대엄범성초필장애적료효화안전성교단용파라서정호，불부능감경환자정신초필，대구체성초필야유량호효과。
Objective To observe the efficacy of conjuncting paroxetine and Chaihu Longgu Muli Tang to treat generalized anxie-ty disorder. Methods 80 cases which met the diagnose of DSM - IV were divided into two groups by random number table method. The treatment group was treated with paroxetine and Chaihu Longgu Muli Tang,and the control group was treated with paroxetine. The period of treatment was 6 ~ 12 months(median is 8. 2 month). Before and after the treatment,all of these cases were evaluated with Hamilton Anxiety Scale - 14 item( HAMA - 14),and before the treatment evaluated with Hamilton Depression Scale - 17 item (HAMD - 17)to evacuate serous depression patients. Results The scores of HAMA - 14 decreased in both of two groups,and the treatment group decreased more in the scores of general,psychogenic anxiety,somatic anxiety,the differences were statistical signifi-cant(P < 0. 05). The dose of paroxetine in the treatment group was less than the control group,the difference was statistical significant (P < 0. 05). Conclusion The conjuncting paroxetine and Chaihu Longgu Muli Tang to treat generalized anxiety disorder is more effec-tive and safe than only using paroxetine.