CAJ | 학술논문

目的：探讨精神分裂症患者临床特征的性别差异。方法连续入组住院治疗的符合《国际疾病分类（第10版）》（ICD -10）精神分裂症诊断标准的患者334例，采用阳性和阴性症状量表（PANSS）、自知力与治疗态度问卷（ITAQ）、药物态度清单（DAI）、副反应量表（TESS）及健康状况问卷（SF -36）测评患者治疗前后的临床特征。采用χ2检验、t 检验及协方差分析对临床特征进行性别差异比较。结果男性患者发病年龄小于女性（P ＜0.05），女性患者已婚比例高（ P ＜0.05），治疗后女性患者 ITAQ 评分、DAI 评分、SF -36评分低于男性（ P 均＜0.05），TESS 评分、PANSS 阳性症状评分及抑郁症状评分高于男性（P 均＜0.05）。结论女性精神分裂症患者与男性相比，发病年龄晚，已婚比例高，抑郁症状重，对药物的副反应敏感。
목적：탐토정신분렬증환자림상특정적성별차이。방법련속입조주원치료적부합《국제질병분류（제10판）》（ICD -10）정신분렬증진단표준적환자334례，채용양성화음성증상량표（PANSS）、자지력여치료태도문권（ITAQ）、약물태도청단（DAI）、부반응량표（TESS）급건강상황문권（SF -36）측평환자치료전후적림상특정。채용χ2검험、t 검험급협방차분석대림상특정진행성별차이비교。결과남성환자발병년령소우녀성（P ＜0.05），녀성환자이혼비례고（ P ＜0.05），치료후녀성환자 ITAQ 평분、DAI 평분、SF -36평분저우남성（ P 균＜0.05），TESS 평분、PANSS 양성증상평분급억욱증상평분고우남성（P 균＜0.05）。결론녀성정신분렬증환자여남성상비，발병년령만，이혼비례고，억욱증상중，대약물적부반응민감。
Objective To explore the gender differences in clinical features of patients with schizophrenia. Methods A conven-ience sample consisted of 334 in - patients with schizophrenia. Clinical features were assessed before and after treatment by the Positive and Negative Syndrome Scale( PANSS),the Insight and Treatment Attitudes Questionnaire( ITAQ),the Drug Attitude Inventory (DAI),the Treatment Emergent Symptoms Scale(TESS),and the Short Form 36 Health Survey Questionnaire(SF - 36). Apply Chi- square test,t - test and covariance analysis to compare the gender differences of clinical features. Results Age of onset was younger in male patients(P < 0. 05),and most female patients were married(P < 0. 05). After treatment,scores of ITAQ,DAI,and health status in female patients were lower than male(P < 0. 05),while scores of TESS,positive symptoms and depressive symptoms of PAN-SS were higher than male(P < 0. 05). Conclusion The following factors were significantly associated with the female schizophrenia patients:later age of onset,married,more severe depressive symptoms and more medication side - effects.