CAJ | 학술논문

目的：通过总结精神分裂症患者合并使用心境稳定剂的现状及其对短期预后的影响，了解患者的获益与风险。方法对纳入的334例精神分裂症患者进行自然观察，按是否合并使用心境稳定剂分组。采用阳性和阴性症状量表（PANSS）、自知力和治疗态度问卷（ITAQ）、副反应量表（TESS）及健康状况量表（SF -36）分别测评精神症状、自知力、药物不良反应及生活质量。结果入院时合并组 PANSS 总评分、兴奋因子、认知因子评分高于未合并组（P ＜0.05）；出院时合并组 PANSS 阳性因子、认知因子评分仍高于未合并组（P ＜0.05）；ITAQ、SF -36精神心理维度评分低于未合并组（P ＜0.05）。结论合并心境稳定剂治疗对精神分裂症患者的兴奋冲动攻击行为有效，但不影响总体症状改善，且对生活质量和自知力可能有负面影响，故使用前应谨慎评估。
목적：통과총결정신분렬증환자합병사용심경은정제적현상급기대단기예후적영향，료해환자적획익여풍험。방법대납입적334례정신분렬증환자진행자연관찰，안시부합병사용심경은정제분조。채용양성화음성증상량표（PANSS）、자지력화치료태도문권（ITAQ）、부반응량표（TESS）급건강상황량표（SF -36）분별측평정신증상、자지력、약물불량반응급생활질량。결과입원시합병조 PANSS 총평분、흥강인자、인지인자평분고우미합병조（P ＜0.05）；출원시합병조 PANSS 양성인자、인지인자평분잉고우미합병조（P ＜0.05）；ITAQ、SF -36정신심리유도평분저우미합병조（P ＜0.05）。결론합병심경은정제치료대정신분렬증환자적흥강충동공격행위유효，단불영향총체증상개선，차대생활질량화자지력가능유부면영향，고사용전응근신평고。
Objective To estimate the benefits and risks of adjunctive mood stabilizer in patients with schizophrenia through sum-marizing its influence on short - term prognosis. Methods The sample of 334 patients with schizophrenia from Guangzhou Brain Hospital were observed naturally,grouped by prescribing adjunctive mood stabilizers. We used Positive and Negative Syndrome Scale(PANSS), Insight and Treatment Attitudes Questionnaire(ITAQ),Treatment Emergent Symptoms Scale(TESS)and Short Form 36 Health Survey Questionnaire(SF -36)to evaluate symptoms,pharmacologic side effects and the quality of life respectively. Results Compared to the group without being prescribed mood stabilizers,patients who combined mood stabilizers had higher scores in exciting factor and cognitive factor of PANSS five - factor model at admission(P <0. 05),and still got higher sores in the positive factor,cognitive factor at discharge (P <0. 05),while their sores of ITAQ and SF -36 mental dimension were lower at discharge(P <0. 05). Conclusion Adjunctive mood stabilizer in patients with schizophrenia is common,and effective for treatment of excited impulse attack effectively,but it does not im-prove the overall symptoms,and may have a negative impact on the quality of life and insight. Therefore,clinicians should assess careful-ly before prescribing.