CAJ | 학술논문

目的：比较右美托咪定及丙泊酚用于剖宫产患者术中镇静的作用。方法选择择期剖宫产患者60例,随机分为2组,每组30例。右美托咪定组在胎儿剖出后即刻注射咪达唑仑1 mg并且泵入右美托咪定1μg/kg,泵注10 min后改为维持量0．6μg/( kg·h)；丙泊酚组在胎儿剖出后即刻注射咪达唑仑1 mg并且泵注丙泊酚2 mg/( kg·h)。两组均采用腰硬联合麻醉。记录患者镇静程度OAA/S评分、术中知晓率、呼吸抑制发生率(术中SpO2<94%)、恶心呕吐发生率、寒战不适发生率以及术后镇痛的满意率。结果两组患者术中镇静程度OAA/S评分及知晓率比较差异无统计学意义( P>0．05),右美托咪定组术中呼吸抑制发生率、恶心呕吐及寒战不适的发生率明显低于丙泊酚组(P<0．01,P<0．05),且术后镇痛满意率高于丙泊酚组(P<0．05)。结论右美托咪定较丙泊酚更适用于剖宫产患者的镇静,可提高患者的舒适度。
목적：비교우미탁미정급병박분용우부궁산환자술중진정적작용。방법선택택기부궁산환자60례,수궤분위2조,매조30례。우미탁미정조재태인부출후즉각주사미체서륜1 mg병차빙입우미탁미정1μg/kg,빙주10 min후개위유지량0．6μg/( kg·h)；병박분조재태인부출후즉각주사미체서륜1 mg병차빙주병박분2 mg/( kg·h)。량조균채용요경연합마취。기록환자진정정도OAA/S평분、술중지효솔、호흡억제발생솔(술중SpO2<94%)、악심구토발생솔、한전불괄발생솔이급술후진통적만의솔。결과량조환자술중진정정도OAA/S평분급지효솔비교차이무통계학의의( P>0．05),우미탁미정조술중호흡억제발생솔、악심구토급한전불괄적발생솔명현저우병박분조(P<0．01,P<0．05),차술후진통만의솔고우병박분조(P<0．05)。결론우미탁미정교병박분경괄용우부궁산환자적진정,가제고환자적서괄도。
Objective To compare the effect of dexmedetomidine and propofol as sedatives in patients with cesarean section. Methods Sixty patients undergoing caesarean section were randomly divided into two groups. Patients in dexmedetomidine group (group D,n=30) were immediately injected 1 mg midazolam and pumped 1 μg/kg of dexmedetomidine after fetal delivery,then the dexmedetomidine was maintained with the amount of 0. 6μg/( kg·h) at 10 min after the first infusion. Patients in propofol group ( group P) received infusion of 1 mg midazo-lam and 2 mg/( kg·h ) propofol after fetal delivery. Combined spinal epidural anesthesia was used in the two groups. The OAA/S score,intraoperative awareness rate,incidences of respiratory depression (SpO2 <94%),nausea/vomiting and chills,the postoperative sedative satisfactory rate were recorded. Results There was no significant differ-ence in OAA/S score and intraoperative awareness rate between the two groups (P>0. 05). The incidences of intraop-erative respiratory inhibition,nausea/vomiting and chills in group D were lower than those of group P (P<0. 05). Conclusion Dexmedetomidine has better sedative effect on patients with caesarean operation than that of propofol and can improve the patients′ comfort level.