CAJ | 학술논문

肿瘤细胞对化疗药物耐药是导致化疗失败的重要原因。肿瘤细胞DNA修复基因的过表达引起DNA损伤后修复并最终导致了耐药性的产生。聚腺苷酸二磷酸核糖基聚合酶（PARP）是具有碱基切除修复功能的DNA单链损伤修复酶，由于其在肿瘤细胞内过表达并在肿瘤细胞DNA损伤修复过程中发挥着重要作用，被认为是肿瘤靶向治疗领域的重要靶点。近年来关于PARP抑制剂的研究屡见报道，发现PARP抑制剂不仅对放化疗具有一定的增敏效果，且在特定基因型瘤种中还具有显著的单独抗肿瘤效应。本文旨在对近年来PARP抑制剂的最新临床研究进展进行综述。
종류세포대화료약물내약시도치화료실패적중요원인。종류세포DNA수복기인적과표체인기DNA손상후수복병최종도치료내약성적산생。취선감산이린산핵당기취합매（PARP）시구유감기절제수복공능적DNA단련손상수복매，유우기재종류세포내과표체병재종류세포DNA손상수복과정중발휘착중요작용，피인위시종류파향치료영역적중요파점。근년래관우PARP억제제적연구루견보도，발현PARP억제제불부대방화료구유일정적증민효과，차재특정기인형류충중환구유현저적단독항종류효응。본문지재대근년래PARP억제제적최신림상연구진전진행종술。
Chemo?resistance is one of the most importance reasons to explain the failure of chemotherapy. The over expression of DNA repairing gene in cancer cells lead to the chemo?resistance. Poly(ADP?ribose) polymerase(PARP) is one of the DNA repai?ring enzymes by excising base which has been supposed to be one of the target of molecular targeting therapy. Recently plenty of PARP?related researches had been reported, which suggested that PARP inhibitors could sensitize chemotherapeutics as well as the anti?tumor effect alone. The text below will summarize the updating clinical researches of PARP inhibitors in recent 5 years.