CAJ | 학술논문

目的：研究半乳凝素-3(Galectin-3)和微小 RNA-21(miRNA-21)在非小细胞肺癌(NSCLC)组织中的表达和临床意义。方法选取150例 NSCLC 患者作为肺癌组,同一时期来该院进行治疗的150例肺部良性病变患者作为对照组。比较两组患者的 Galectin-3和 miRNA-21的表达水平,分析它们与患者临床特征的相关性。结果肺癌组患者的 Galectin-3为6.75±2.38, miRNA-21为5.91±1.59；肺癌组患者的 Galectin-3为1.12±0.29,miRNA-21为0.97±0.17,差异具有统计学意义(P <0.05)。Galectin-3的水平与临床分期、分化程度、肿瘤直径、淋巴结转移和患者的无进展生存期(PFS)和总生存期(OS)有明显相关性(P <0.05)。miRNA-21水平与临床分期、分化程度、肿瘤直径和患者的 PFS 和 OS 有明显的相关性(P <0.05)。Galectin-3敏感度为90.20%,特异度为70.69%；miRNA-21的敏感度为88.24%,特异度为69.97%,差异无统计学意义(P >0.05)。结论Ga-lectin-3和 miRNA-21的表达水平在 NSCLC 的诊断和预后判断中具有一定的应用价值。
목적：연구반유응소-3(Galectin-3)화미소 RNA-21(miRNA-21)재비소세포폐암(NSCLC)조직중적표체화림상의의。방법선취150례 NSCLC 환자작위폐암조,동일시기래해원진행치료적150례폐부량성병변환자작위대조조。비교량조환자적 Galectin-3화 miRNA-21적표체수평,분석타문여환자림상특정적상관성。결과폐암조환자적 Galectin-3위6.75±2.38, miRNA-21위5.91±1.59；폐암조환자적 Galectin-3위1.12±0.29,miRNA-21위0.97±0.17,차이구유통계학의의(P <0.05)。Galectin-3적수평여림상분기、분화정도、종류직경、림파결전이화환자적무진전생존기(PFS)화총생존기(OS)유명현상관성(P <0.05)。miRNA-21수평여림상분기、분화정도、종류직경화환자적 PFS 화 OS 유명현적상관성(P <0.05)。Galectin-3민감도위90.20%,특이도위70.69%；miRNA-21적민감도위88.24%,특이도위69.97%,차이무통계학의의(P >0.05)。결론Ga-lectin-3화 miRNA-21적표체수평재 NSCLC 적진단화예후판단중구유일정적응용개치。
Objective To study the expression level and clinical significance of Galectin-3 and miRNA-21 in non-small-cell lung carcinoma(NSCLC).Methods One hundred and fifty patients with NSCLC were chosen as cancer group,and 1 50 patients with benign pulmonary diseases were chosen as control group.The expression level of Galectin-3 and that of miRNA-21 between two groups were compared,and the relevance between expression level of Galectin-3 and that of miRNA-21 and clinical feature were analysed.Results In cancer group,the expression level of Galectin-3 was 6.75±2.38,and that of control group was 1.12 ±0.29;the expression level of miRNA-21 was 5.91 ± 1.59,and that of control group was 0.97 ± 0.1 7,and the difference between two groups had statistical significance(P <0.05 ).The relevance between expression level of Galectin-3 and stage,differentiation,lym-phatic metastasis,diameter of carcinoma and PFS,OS of patients had statistical significance(P <0.05).The relevance between ex-pression level of miRNA-21 and stage,differentiation,diameter of carcinoma and PFS,OS of patients had statistical significance(P <0.05).In the diagnosis of NSCLC,the sensitivity of the expression level of Galectin-3 was 90.20%,and its specificity was 70.69%, while the sensitivity of expression level of miRNA-21 was 88.24% and its specificity was 69.97%.The difference between the di-agnostic value of Galectin-3 and that of miRNA-21 had no statistical significance(P >0.05 ).Conclusion The expression level of Galectin-3 and that of miRNA-21 can be applied in the diagnosis and prognosis of non-small-cell lung carcinoma.