CAJ | 학술논문

目的：研究探讨慢性复发性丙型肝炎的优化治疗方案及其最新研究。方法选择2008年5月至2012年5月至该院传染病科就诊的慢性复发性丙肝的患者50例，分为两组，每组25例，甲组采用标准治疗延长疗程方案，乙组采用标准治疗加大剂量方案，通过观察两组的持续病毒学应答(SVR)来比较两组治疗方法的效果，并观察6个月后的复发情况。结果甲组获得32%的 SVR 率，乙组获得23%的 SVR 率；6个月后甲组的复发率为38%，乙组为43%，差异均有统计学意义(P <0.05)。结论甲组的标准治疗延长疗程方案的临床 SVR 率高于乙组。
목적：연구탐토만성복발성병형간염적우화치료방안급기최신연구。방법선택2008년5월지2012년5월지해원전염병과취진적만성복발성병간적환자50례，분위량조，매조25례，갑조채용표준치료연장료정방안，을조채용표준치료가대제량방안，통과관찰량조적지속병독학응답(SVR)래비교량조치료방법적효과，병관찰6개월후적복발정황。결과갑조획득32%적 SVR 솔，을조획득23%적 SVR 솔；6개월후갑조적복발솔위38%，을조위43%，차이균유통계학의의(P <0.05)。결론갑조적표준치료연장료정방안적림상 SVR 솔고우을조。
Objective To optimize the treatment of chronic hepatitis C recurrence.Methods During May 2008 to May 2012, 50 patients with chronic recurrent hepatitis C were chosen in the infectious department of our hospital.They were divided into two groups with 25 cases in each group.Group A was treated by standard extended treatment scheme,while Group B was treated by standard large dose scheme.The effect was estimated by the observation of sustained virologic response in the two groups (sus-tained virologic response,SVR).Results 32% SVR rate was found in group A and 23% SVR rate was found in Group B.38% re-currence rate appeared in group A after six months and 43% recurrence rate occurred in group B,there were significant difference between two groups(P <0.05).Conclusion The standard extended treatment schemes of pegylated interferon and ribavirin is su-perior to group B in SVR rate.