CAJ | 학술논문

目的：研究组合式血液净化模式对 MODS患者胰岛素抵抗的影响，探讨改善 MODS患者胰岛素抵抗最佳血液净化模式。方法选取 MODS 患者60例，随机分为试验组(单一血液净化模式)和对照组(组合式血液净化模式)，每组各30例。观察两组患者血糖(BG)、血糖标准差(BGSD)、血糖变异系数(BGCV)、普通胰岛素用量(Ins)、空腹胰岛素(FINS)、胰岛素抵抗指数(HOMA-IR)、糖化血红蛋白(HbA1c)、C 反应蛋白(CRP)及试验组治疗前后指标变化情况。结果试验组 BG、HbA1c、FINS、CRP、HOMA-IR、Ins 均较对照组降低(P <0.05)；试验组治疗前较治疗后 BG、FINS、CRP、HOMA-IR、Ins 均有下降(P <0.05)， HbA1c 无改善(P >0.05)。结论组合血液净化模式对 MODS 患者胰岛素抵抗的疗效明确，但其机制需进一步研究。
목적：연구조합식혈액정화모식대 MODS환자이도소저항적영향，탐토개선 MODS환자이도소저항최가혈액정화모식。방법선취 MODS 환자60례，수궤분위시험조(단일혈액정화모식)화대조조(조합식혈액정화모식)，매조각30례。관찰량조환자혈당(BG)、혈당표준차(BGSD)、혈당변이계수(BGCV)、보통이도소용량(Ins)、공복이도소(FINS)、이도소저항지수(HOMA-IR)、당화혈홍단백(HbA1c)、C 반응단백(CRP)급시험조치료전후지표변화정황。결과시험조 BG、HbA1c、FINS、CRP、HOMA-IR、Ins 균교대조조강저(P <0.05)；시험조치료전교치료후 BG、FINS、CRP、HOMA-IR、Ins 균유하강(P <0.05)， HbA1c 무개선(P >0.05)。결론조합혈액정화모식대 MODS 환자이도소저항적료효명학，단기궤제수진일보연구。
Objective To study the effect of combination mode of blood purification on insulin resistance in MODS patients and discuss the best mode of blood purification to improve insulin resistance in MODS patients.Methods A total of 60 MODS pa-tients were selected and randomly divided into control group(single mode of blood purification)and treatment group(combination mode of blood purification),each group of 30 cases.Blood glucose (BG),glucose standard deviation (BGSD),coefficient of variation of blood glucose (BGCV),regular insulin dosage (Ins),fasting insulin (FINS),insulin resistance index (HOMA-IR),HbA1c,C-re-active protein (CRP)was observed before and after treatment.Results BG,HbA1c,FINS,CRP,HOMA-IR,Ins of experimental group was lower than that of control group (P <0.05).After treatment,BG,FINS,CRP,HOMA-IR,Ins was declined in experi-mental group (P <0.05).After treatment,HbA1c was not changed in experimental group (P >0.05 ).Conclusion Combination mode blood purification may be more effective to insulin resistance in MODS patients.